Journal ArticleDOI
ppGpp: magic beyond RNA polymerase
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TLDR
How bacteria exploit ppGpp to modulate the synthesis, stability or activity of proteins or regulatory RNAs that are crucial in challenging environments are discussed, using mechanisms beyond the direct regulation of RNAP activity.Abstract:
During stress, bacteria undergo extensive physiological transformations, many of which are coordinated by ppGpp. Although ppGpp is best known for enhancing cellular resilience by redirecting the RNA polymerase (RNAP) to certain genes, it also acts as a signal in many other cellular processes in bacteria. After a brief overview of ppGpp biosynthesis and its impact on promoter selection by RNAP, we discuss how bacteria exploit ppGpp to modulate the synthesis, stability or activity of proteins or regulatory RNAs that are crucial in challenging environments, using mechanisms beyond the direct regulation of RNAP activity.read more
Citations
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Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence.
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Biofilm infections, their resilience to therapy and innovative treatment strategies
Ute Römling,Carlos Balsalobre +1 more
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Recent functional insights into the role of (p)ppGpp in bacterial physiology
TL;DR: This Review summarizes recent insights on the molecular mechanisms governing the activity of the RelA/SpoT homologue (RSH) proteins, which are key players that regulate the cellular levels of (p)ppGpp.
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Bacterial Persister Cell Formation and Dormancy
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Genomic Expansion of Domain Archaea Highlights Roles for Organisms from New Phyla in Anaerobic Carbon Cycling
Cindy J. Castelle,Kelly C. Wrighton,Brian C. Thomas,Laura A. Hug,Christopher T. Brown,Michael J. Wilkins,Kyle R. Frischkorn,Susannah G. Tringe,Andrea Singh,Lye Meng Markillie,Ronald C. Taylor,Kenneth H. Williams,Jillian F. Banfield +12 more
TL;DR: This study sequenced DNA from complex sediment and planktonic consortia from an aquifer adjacent to the Colorado River and reconstructed the first complete genomes for Archaea using cultivation-independent methods, which dramatically expand genomic sampling of the domain Archaea and clarify taxonomic designations within a major superphylum.
References
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Aminoglycoside antibiotics induce bacterial biofilm formation
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Journal ArticleDOI
(p)ppGpp: still magical?
TL;DR: (p)ppGpp can contribute to regulation of many aspects of microbial cell biology that are sensitive to changing nutrient availability: growth, adaptation, secondary metabolism, survival, persistence, cell division, motility, biofilms, development, competence, and virulence.
Journal ArticleDOI
Evolving concepts in biofilm infections
TL;DR: Several pathogens associated with chronic infections, including Pseudomonas aeruginosa in cystic fibrosis pneumonia, Haemophilus influenzae and Streptococcus pneumoniae in chronic otitis media, and enteropathogenic Escherichia coli in recurrent urinary tract infections, are linked to biofilm formation.