Journal ArticleDOI
Precolumn fluorescence labeling method for simultaneous determination of hydroxyzine and cetirizine in human serum.
Sherin F. Hammad,Mokhtar M. Mabrouk,Ahmed A. Habib,Hamed M. El-Fatatry,Naoya Kishikawa,Kenichiro Nakashima,Naotaka Kuroda +6 more
TLDR
A highly selective and sensitive method was developed for simultaneous determination of the antihistaminic drug hydroxyzine and its pharmacologically active metabolite cetirizine in human serum using haloperidol as internal standard.Abstract:
A highly selective and sensitive method was developed for simultaneous determination of the antihistaminic drug hydroxyzine (HZ) and its pharmacologically active metabolite cetirizine (CZ) in human serum using haloperidol as internal standard. The method was based on fluorescence labeling of both drugs with a fluorescent arylboronic acid 4-(4,5-diphenyl-1H-imidazol-2-yl)phenyl boronic acid followed by separation on silica column using a mobile phase consisting of acetonitrile and water (90:10, v/v%) containing triethylamine and acetic acid. The labeling reaction conditions were optimized and the liquid–liquid extraction method was successfully applied to extract the both drugs from serum. The linearity range was 0.025–2.00 µg/mL for HZ and CZ. The limit of detection (S/N = 3) was 10 and 5 ng/mL for HZ and CZ, respectively. Copyright © 2007 John Wiley & Sons, Ltd.read more
Citations
More filters
Journal ArticleDOI
High throughput method for the analysis of cetrizine hydrochloride in pharmaceutical formulations and in biological fluids using a tris(2,2'-bipyridyl)ruthenium(II)-peroxydisulphate chemiluminescence system in a two-chip device
Haider A. J. Al Lawati,Eiman Al Gharibi,Salma M. Z. Al Kindy,Fakhr Eldin O. Suliman,Ali Al-Lawati +4 more
TL;DR: A fast, economic and sensitive chemiluminescence (CL) method has been developed for the analysis of cetrizine hydrochloride (CET) in pharmaceutical formulations and in biological fluids, and various parameters that influence the CL signal intensity were optimized.
Journal ArticleDOI
Enantioselective determination of cetirizine in human plasma by normal-phase liquid chromatography–atmospheric pressure chemical ionization–tandem mass spectrometry
Seung Woo Kang,Hae Jong Jang,Victor S. Moore,Ji Young Park,Kyoung-Ah Kim,Jeong-Rok Youm,Sang Beom Han +6 more
TL;DR: The proposed method was successfully applied to the study of enantioselective oral pharmacokinetics of levocetirizine in healthy Korean volunteers and the method validation parameters, such as precision, accuracy, and stability, were very satisfactory.
Journal ArticleDOI
Development and validation of a GC-MS method for the determination of hydroxyzine and its active metabolite, cetirizine, in whole blood.
Maria Katselou,Sotiris Athanaselis,Panagiota Nikolaou,Artemisia Dona,Chara Spiliopoulou,Ioannis Papoutsis +5 more
TL;DR: A simple, rapid, sensitive and accurate gas chromatography–mass spectrometric method was developed and validated for the simultaneous determination of hydroxyzine and cetirizine in whole blood and successfully applied during the investigation of clinical cases where these two antihistamines were detected.
Journal ArticleDOI
New Method Development for Hydroxyzine Determination: Application in Stability Studies, Pharmaceutical Formulations, and Humane Serum
TL;DR: In this paper, a low cost, fast, sensitive, and accurate RP-HPLC method for quantitative analysis of HZ was developed and validated using a Hibar μBondapak C18 column as the stationary phase and acetonitrile:methanol:buffer as the mobile phase.
Journal ArticleDOI
Analysis for commonly prescribed non-sedating antihistamines
TL;DR: A comprehensive review with 185 references for the analysis of commonly prescribed members of an important class of drugs, non-sedating antihistamines (NSAs), is presented.
References
More filters
Journal ArticleDOI
Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
TL;DR: In this paper, a cross-coupling reaction is proposed for coupling 1 -Alkenylboron Derivatives: Synthesis of Conjugated Dienes 6.
Journal ArticleDOI
Recent advances in the cross-coupling reactions of organoboron derivatives with organic electrophiles, 1995–1998
TL;DR: The palladium-catalyzed cross-coupling reaction between organoboron compounds and organic halides or triflates provides a powerful and general methodology for the formation of carbon-carbon bonds as discussed by the authors.
Journal ArticleDOI
Recent applications of the Suzuki–Miyaura cross-coupling reaction in organic synthesis
Journal ArticleDOI
Simultaneous screening for 238 drugs in blood by liquid chromatography–ionspray tandem mass spectrometry with multiple-reaction monitoring
TL;DR: A liquid chromatography-tandem mass spectrometry method is presented for the qualitative screening for 238 drugs in blood samples, which is considerably more than in previous methods.
Journal Article
Receptor effects of cetirizine.
Snyder Sh,Snowman Am +1 more
TL;DR: It is suggested that cetirizine's reduced incidence of sedative side effects may stem part from its selectivity for H1 receptors over sites involved in sedation, and partly from its relative exclusion from the CNS.
Related Papers (5)
Gas chromatographic identification and quantification of hydroxyzine: Application in a fatal self-poisoning
Determination of cetirizine in human urine by high-performance liquid chromatography.
Marie Rosseel,Romain Lefebvre +1 more