Predicting pain relief: Use of pre-surgical trigeminal nerve diffusion metrics in trigeminal neuralgia
TLDR
It is demonstrated that pre-surgical DTI metrics can serve as a highly predictive, individualized tool to prognosticate surgical response and confirm the axiom that central pain does not commonly benefit from peripheral treatments.About:
This article is published in NeuroImage: Clinical.The article was published on 2017-01-01 and is currently open access. It has received 62 citations till now. The article focuses on the topics: Trigeminal neuralgia & Trigeminal nerve.read more
Citations
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Neuropathic Pain: From Mechanisms to Treatment
TL;DR: Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a common chronic pain condition with major impact on quality of life and the major classes of therapeutics include drugs acting on α2 δsubunits of calcium channels, sodium channels, and descending modulatory inhibitory pathways.
Journal ArticleDOI
Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities.
Karen D. Davis,Karen D. Davis,Nima Aghaeepour,Andrew H. Ahn,Martin S. Angst,David Borsook,Ashley Brenton,Michael E. Burczynski,Christopher Crean,Robert R. Edwards,Brice Gaudilliere,Georgene W. Hergenroeder,Michael J. Iadarola,Smriti Iyengar,Yunyun Jiang,Jiang-Ti Kong,Sean Mackey,Carl Y. Saab,Christine N. Sang,Joachim Scholz,Märta Segerdahl,Irene Tracey,Christin Veasley,Jing Wang,Tor D. Wager,Ajay D. Wasan,Mary Ann Pelleymounter +26 more
TL;DR: The NIH-led Discovery and Validation of Biomarkers to Develop Non-Addictive Therapeutics for Pain workshop convened scientific leaders from academia, industry, government and patient advocacy groups to discuss progress, challenges, gaps and ideas to facilitate the development of biomarkers and end points for pain.
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Advances in diagnosis, classification, pathophysiology, and management of trigeminal neuralgia.
Lars Bendtsen,Joanna M Zakrzewska,Tone Bruvik Heinskou,Mojgan Hodaie,Mojgan Hodaie,Paulo Roberto Lacerda Leal,Paulo Roberto Lacerda Leal,Turo Nurmikko,Mark Obermann,Giorgio Cruccu,Stine Maarbjerg +10 more
TL;DR: Advances in neuroimaging techniques and animal models will provide further insight into the causes of trigeminal neuralgia and its pathophysiology and development of more efficacious treatment options is highly warranted.
Journal ArticleDOI
Neuroimaging-based biomarkers for pain: state of the field and current directions.
TL;DR: This review explicates the need for brain-based biomarkers for pain, some of their potential uses, and some of the most popular machine learning approaches that have been brought to bear.
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Early postsurgical diffusivity metrics for prognostication of long-term pain relief after Gamma Knife radiosurgery for trigeminal neuralgia.
Sarasa Tohyama,Sarasa Tohyama,Peter Shih-Ping Hung,Peter Shih-Ping Hung,Jidan Zhong,Mojgan Hodaie +5 more
TL;DR: It is demonstrated that early postsurgical target diffusivity metrics have a translational, clinical value and permit prediction of long-term pain relief in patients with TN treated with GKRS.
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