Journal ArticleDOI
Prednisolone reduces preconceptual endometrial natural killer cells in women with recurrent miscarriage
TLDR
It is demonstrated that high numbers of uNK in preimplantation endometrium of women with recurrent miscarriage can be reduced with administration of prednisolone.About:Ā
This article is published in Fertility and Sterility.The article was published on 2005-10-01. It has received 187 citations till now. The article focuses on the topics: Recurrent miscarriage.read more
Citations
More filters
Journal ArticleDOI
Cyclic decidualization of the human endometrium in reproductive health and failure.
Birgit Gellersen,Jan J. Brosens +1 more
TL;DR: The endocrine, paracrine, and autocrine cues that tightly govern this differentiation process are reviewed and how disorders that subvert the programming, initiation, or progression of decidualization compromise reproductive health and predispose for pregnancy failure is discussed.
Journal ArticleDOI
Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage
TL;DR: It is recommended that basic investigations of a couple presenting with recurrent miscarriage should include obstetric and family history, age, BMI and exposure to toxins, full blood count, antiphospholipid antibodies, parental karyotype, pelvic ultrasound and/or hysterosalpingogram.
Journal ArticleDOI
Control of human trophoblast function
TL;DR: The mechanisms which regulate trophoblast differentiation, proliferation, migration and invasiveness are described, and the alterations in these mechanisms which lead to pathological conditions are explained.
Journal ArticleDOI
Evidence-based investigations and treatments of recurrent pregnancy loss.
Ole Bjarne Christiansen,Anne-Marie Nybo Andersen,Ernesto Bosch,Salim Daya,Peter J. Delves,Thomas Vauvert F. Hviid,William H. Kutteh,Susan Laird,Tin-Chiu Li,Katrin van der Ven +9 more
TL;DR: At present, the clinician must base their clinical practice on the few high-quality observational studies and intervention trials available rather than on meta-analyses, as there is a scarcity of good clinical trials.
Journal ArticleDOI
Uterine natural killer cells: a specialized differentiation regulated by ovarian hormones
TL;DR: During successful murine pregnancy, uNK cells appear to regulate initiation of structural changes in the feed arterial systems that support maternal endometrial tissue at sites of implantation and subsequent placental development, creating a higher volume arterial bed with flaccid vessels unresponsive to vasoactive compounds.
References
More filters
Journal ArticleDOI
Dating the endometrial biopsy.
TL;DR: It is asserted that examination of the endometrium during the secretory phase yields more information about the time of ovulation degree of progestational change and normality of theendometrium than any other test used in sterility studies.
Journal ArticleDOI
Natural killer cells and pregnancy.
TL;DR: No convincing evidence of uterine maternal T-cell recognition of placental trophoblast cells has been found, but instead, there might be maternal allorecognition mediated by uterine natural killer cells that recognize unusual fetal trophOBlast MHC ligands.
Journal ArticleDOI
Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success
Susan E. Hiby,James J. Walker,Kevin M. O'Shaughnessy,Christopher W.G. Redman,Mary Carrington,John Trowsdale,Ashley Moffett +6 more
TL;DR: In this article, the authors tested the idea that recognition of these molecules by killer immunoglobulin receptors (KIRs) on maternal decidual NK cells is a key factor in the development of preeclampsia.
Journal Article
Endometrial T, B, and NK cells in patients with recurrent spontaneous abortion. Altered profile and pregnancy outcome.
TL;DR: Endometrial lymphocytes of recurrent spontaneous aborters harbor a distinct immunophenotypic profile that antedates implantation and suggests that endometrial immunologic conditions are intrinsically altered in recurrent aborters, as well as suggesting a role for NK cells in the abortion process.
Journal ArticleDOI
A longitudinal study of pregnancy outcome following idiopathic recurrent miscarriage
TL;DR: Data from this large study group have enabled accurate prediction of future pregnancy success and have established important gestational milestones for women with idiopathic recurrent miscarriage.