Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis
TLDR
The bidirectional interactions between hormones and the immune system contribute to both the outcome of pregnancy and female susceptibility to disease.About:
This article is published in Hormones and Behavior.The article was published on 2012-08-01 and is currently open access. It has received 512 citations till now. The article focuses on the topics: Immune system & Pregnancy.read more
Citations
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Pregnancy and Infection
TL;DR: This review includes an update on immunologic alterations during pregnancy, and an increased severity of infections with some organisms, including influenza virus, hepatitis E virus, herpes simplex virus, and malaria parasites.
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The immune system and developmental programming of brain and behavior
Staci D. Bilbo,Jaclyn M. Schwarz +1 more
TL;DR: The goal of this review is to describe the important role of the immune system during brain development, and to discuss some of the many ways in which immune activation during early brain development can affect the later-life outcomes of neural function, immune function, mood and cognition.
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Influenza Vaccination of Pregnant Women and Protection of Their Infants
Abstr Act,Shabir A. Madhi,Clare L. Cutland,Locadiah Kuwanda,Adriana Weinberg,Andrea Hugo,Stephanie Jones,Peter V. Adrian,Nadia van Niekerk,Florette K. Treurnicht,Justin R. Ortiz,Marietjie Venter,Avy Violari,Kathleen M. Neuzil,Keith P. Klugman,Marta C. Nunes +15 more
TL;DR: Influenza vaccine was immunogenic in HIV-uninfected and HIV-infected pregnant women and provided partial protection against confirmed influenza in both groups of women and in infants who were not exposed to HIV.
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A retrospective cohort study: 10-year trend of disease-modifying antirheumatic drugs and biological agents use in patients with rheumatoid arthritis at Veteran Affairs Medical Centers.
TL;DR: Methotrexate use increased as it became the preferred first-line agent, while other traditional agents declined, and a significant shorter time between RA diagnosis and DMARD or biological agent initiation in recent years suggests improvements in quality of care.
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The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation
TL;DR: The changes that occur in maternal physiology in response to pregnancy and the significance of placental hormone production in mediating such changes are examined.
References
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Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?
TL;DR: In this article, the authors hypothesize that TH2 cytokines inhibit TH1 responses, improving fetal survival but impairing responses against some pathogens, since pregnant females are susceptible to intracellular pathogens and are biased towards humoral rather than cell mediated immunity.
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The complex role of estrogens in inflammation
TL;DR: This review reinforces the concept that estrogens have antiinflammatory but also proinflammatory roles depending on above-mentioned criteria and explains that a uniform concept as to the action of estrogens cannot be found for all inflammatory diseases due to the enormous variable responses of immune and repair systems.
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Rate of Pregnancy-Related Relapse in Multiple Sclerosis
Christian Confavreux,Michael Hutchinson,Martine Hours,Cortinovis-Tourniaire P,Thibault Moreau +4 more
TL;DR: This study studied 254 women with multiple sclerosis during 269 pregnancies in 12 European countries to determine the rate of relapse per trimester and the score on the Kurtzke Expanded Disability Status Scale.
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H1N1 2009 influenza virus infection during pregnancy in the USA
Denise J. Jamieson,Margaret A. Honein,Sonja A. Rasmussen,Jennifer Williams,David L. Swerdlow,Matthew Biggerstaff,Stephen Lindstrom,Janice K. Louie,Cara M. Christ,Susan Bohm,Vincent P. Fonseca,Kathleen A. Ritger,Daniel J Kuhles,Paula Eggers,Hollianne Bruce,Heidi A Davidson,Emily Lutterloh,Meghan L. Harris,Colleen Burke,Noelle M. Cocoros,Lyn Finelli,Kitty MacFarlane,Bo Shu,Sonja J Olsen +23 more
TL;DR: Cases and deaths associated with pandemic H1N1 virus in pregnant women identified in the USA during the first month of the present outbreak lend support to the present recommendation to promptly treat pregnant women with H 1N1 influenza virus infection with anti-influenza drugs.
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Th 1-type immunity is incompatible with successful pregnancy
TL;DR: Evidence from murine and human pregnancy is presented to show that, since Th1-type cytokines mediate pregnancy loss, a shift towards Th2-type immunity may help resolve 'unexplained' pregnancy failure.