Journal ArticleDOI
Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin.
Tetsuro Shingo,Christopher Gregg,Emeka Enwere,Hirokazu Fujikawa,Rozina Hassam,Colleen Geary,James C. Cross,Samuel Weiss +7 more
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TLDR
It is shown that the production of neuronal progenitors is stimulated in the forebrain subventricular zone of female mice during pregnancy and that this effect is mediated by the hormone prolactin, implying that forebrain olfactory neurogenesis may contribute to adaptive behaviors in mating and pregnancy.Abstract:
Neurogenesis occurs in the olfactory system of the adult brain throughout life, in both invertebrates and vertebrates, but its physiological regulation is not understood. We show that the production of neuronal progenitors is stimulated in the forebrain subventricular zone of female mice during pregnancy and that this effect is mediated by the hormone prolactin. The progenitors then migrate to produce new olfactory interneurons, a process likely to be important for maternal behavior, because olfactory discrimination is critical for recognition and rearing of offspring. Neurogenesis occurs even in females that mate with sterile males. These findings imply that forebrain olfactory neurogenesis may contribute to adaptive behaviors in mating and pregnancy.read more
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Adult neurogenesis in the mammalian central nervous system
Guo Li Ming,Hongjun Song +1 more
TL;DR: Advances in the understanding of adult neurogenesis will not only shed light on the basic principles of adult plasticity, but also may lead to strategies for cell replacement therapy after injury or degenerative neurological diseases.
Journal ArticleDOI
Adult neurogenesis and functional plasticity in neuronal circuits
TL;DR: This work has shown that in two areas of the adult brain, new neurons are generated throughout life and form an integral part of the normal functional circuitry, revealing a plastic mechanism by which the brain's performance can be optimized for a given environment.
Journal ArticleDOI
Critical period regulation.
TL;DR: This review summarizes the current understanding of known critical periods across several systems and species and delineates a number of emerging principles: functional competition between inputs, role for electrical activity, structural consolidation, regulation by experience, special role for inhibition in the CNS, potent influence of attention and motivation, unique timing and duration.
Journal ArticleDOI
Adult neurogenesis: from precursors to network and physiology.
TL;DR: An overview of the current knowledge on adult neurogenesis and its functional relevance for the adult brain is proposed and a growing list of epigenetic factors that display a specificity of action depending on the neurogenic site under consideration has been identified.
Journal ArticleDOI
Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain
Zaman Mirzadeh,Florian T. Merkle,Mario Soriano-Navarro,José Manuel García-Verdugo,Arturo Alvarez-Buylla +4 more
TL;DR: It is shown that SVZ B1 cells in adult mice extend a minute apical ending to directly contact the ventricle and a long basal process ending on blood vessels, significantly reshaping the understanding of this adult neurogenic niche.
References
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Journal ArticleDOI
Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
Brent A. Reynolds,Samuel Weiss +1 more
TL;DR: Cells of the adult mouse striatum have the capacity to divide and differentiate into neurons and astrocytes.
Journal ArticleDOI
Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain
Fiona Doetsch,Isabelle Caillé,Daniel A. Lim,José Manuel García-Verdugo,Arturo Alvarez-Buylla +4 more
TL;DR: It is shown that SVZ astrocytes act as neural stem cells in both the normal and regenerating brain and give rise to cells that grow into multipotent neurospheres in vitro.
Journal ArticleDOI
Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Joseph Altman,Gopal D. Das +1 more
TL;DR: It is postulated that undifferentiated cells migrate postnatally from the forebrain ventricles to the hippocampus where they become differentiated, implicating that they may function as receptors of gonadal hormones.
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Neuronal replacement from endogenous precursors in the adult brain after stroke
TL;DR: It is shown that stroke, caused by transient middle cerebral artery occlusion in adult rats, leads to a marked increase of cell proliferation in the subventricular zone, and stroke induces differentiation of new neurons into the phenotype of most of the neurons destroyed by the ischemic lesion.
Journal ArticleDOI
Long-distance neuronal migration in the adult mammalian brain
TL;DR: Grafted and endogenous SVZ cells in the lateral ventricle of adult mice migrate long distances and differentiate into neurons in the olfactory bulb.
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