Journal ArticleDOI
Preparation and evaluation of solid lipid nanoparticles with JSH18 for skin-whitening efficacy.
Jae-Woo So,Sujin Kim,Jeong-Sook Park,Bong-Hee Kim,Sang-Hun Jung,Sang-Chul Shin,Cheong-Weon Cho +6 more
TLDR
Topical formulations such as creams including SLNs with JSH18 might be an appropriate carrier for skin-whitening agents, according to this study.Abstract:
A new molecule having the structure of 6-methyl-3-phenethyl-3,4-dihydro-1H-quinazoline-2-thione (JSH18) was synthesized and it was possibly presupposed to show depigmentation through the inhibition of tyrosinase which is involved in the formation of melanin. Therefore, we are going to develop JSH18 as an inhibitor of melanin synthesis with topical formulations to show its optimal efficiency for skin whitening. Solid lipid nanoparticles (SLNs) play an important role as drug delivery systems for intravenous, peroral, parenteral, or ocular administration and for topical delivery. The particle size of prepared SLNs of JSH18 was variable from 59.8–919.6 nm. When the optimal SLNs cream (PU3) including 4 uM of JSH18 was applied to the backs of hairless rats for four days after the backs were irradiated by UV ray for seven days and the skin color was checked by reflectance spectrophotometer, the rat skin applied with PU3 cream quickly recovered to normal compared to SLNs cream without JSH18. Taken together, this ...read more
Citations
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Journal ArticleDOI
Nanoparticles and microparticles for skin drug delivery
Tarl W. Prow,Jeffrey E. Grice,Lynlee L. Lin,Rokhaya Faye,Margaret K. Butler,Wolfgang Becker,Elisabeth M. T. Wurm,Corinne Yoong,Thomas Robertson,Thomas Robertson,H. Peter Soyer,Michael S. Roberts,Michael S. Roberts +12 more
TL;DR: Unpublished clinical data on nanoparticle penetration and previously published reports support the hypothesis that nanoparticles >10nm in diameter are unlikely to penetrate through the stratum corneum into viable human skin but will accumulate in the hair follicle openings, especially after massage.
Journal ArticleDOI
Nanotechnology for the development of new cosmetic formulations
Ana Cláudia Santos,Francisca Morais,Ana Simões,Irina Pereira,Joana Sequeira,Miguel Pereira-Silva,Francisco Veiga,António J. Ribeiro +7 more
TL;DR: This innovative and timely review emphasizes that nanosystems constitute a highly promising technology strategy towards the obtainment of superior and ground-breaking cosmetic formulations.
Journal ArticleDOI
Nanomaterials for transdermal drug delivery: beyond the state of the art of liposomal structures
TL;DR: While passive approaches dominate the literature and the transdermal market, active delivery based on microneedles or iontophoresis approaches have shown great promise for transDermal drug delivery and have entered the market, in the last decade.
Journal ArticleDOI
Increased therapeutic efficacy of a newly synthesized tyrosinase inhibitor by solid lipid nanoparticles in the topical treatment of hyperpigmentation.
Al-Amin,Jiafu Cao,Muhammad Naeem,Hasanul Banna,Min-Soo Kim,Yunjin Jung,Hae Young Chung,Hyung Ryong Moon,Jin-Wook Yoo +8 more
TL;DR: Data indicate that MHY-SLNs show promise in the topical treatment of hyperpigmentation as a highly effective and nontoxic means to deliver a newly synthesized potent tyrosinase inhibitor and to target melanocytes through the skin.
Journal ArticleDOI
Nanotechnology in cosmetics pros and cons
TL;DR: The use of nanomaterials in the field of cosmetics can have two sides as health-related benefits and detrimental effects as mentioned in this paper, and the study regarding the toxic effects on the health also equally matters.
References
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Journal ArticleDOI
Solid lipid nanoparticles: Production, characterization and applications
W. Mehnert,Karsten Mäder +1 more
TL;DR: An overview about the selection of the ingredients, different ways of SLN production and SLN applications, and the in vivo fate of the carrier are presented.
Journal ArticleDOI
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations.
TL;DR: As a novel type of lipid nanoparticles with solid matrix, the nanostructured lipid carriers (NLC) are presented and improvements discussed, for example, increase in loading capacity, physical and chemical long-term stability, triggered release and potentially supersaturated topical formulations.
Journal ArticleDOI
Tyrosinase: a comprehensive review of its mechanism.
Álvaro Sánchez-Ferrer,José Neptuno Rodríguez-López,Francisco García-Cánovas,Francisco García-Carmona +3 more
Journal ArticleDOI
Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future.
Y.-J. Kim,Hiroshi Uyama +1 more
TL;DR: This article overviews the various inhibitors obtained from natural and synthetic sources with their industrial importance, and examines the role of tyrosinase in melanin biosynthesis and its role in dermatological disorders.
Journal ArticleDOI
Mammalian tyrosinase catalyzes three reactions in the biosynthesis of melanin
Ann Körner,John M. Pawelek +1 more
TL;DR: Tyrosinase, purified from murine melanomas and the skins of brown mice, has now been shown to catalyze a third reaction in mammalian melanogenesis, namely the conversion of 5,6-dihydroxyindile to melanochrome.