Open AccessJournal Article
Preparing the wound bed--debridement, bacterial balance, and moisture balance.
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TLDR
The authors demonstrate that the treatment of chronic wounds can be accomplished through a series of recommendations and rationales based on the literature and their experience, which lay the groundwork for thorough assessment and evaluation of the wound.Abstract:
Successful diagnosis and treatment of patients with chronic wounds involve holistic care and a team approach. The integration of the work of an interdisciplinary care team that includes doctors, nurses, and allied health professionals with the patient, family, significant others, and caregivers offers an optimal formula for achieving wound resolution. Such an approach challenges practitioners and everyone participating in wound care to integrate data and information that arise from a number of sources and mitigating factors. In this article, the authors define the changing paradigm that links treatment of the cause and focuses on three components of local wound care: debridement, wound-friendly moist interactive dressings, and bacterial balance. The authors demonstrate that the treatment of chronic wounds can be accomplished through a series of recommendations and rationales based on the literature and their experience. These recommendations lay the groundwork for thorough assessment and evaluation of the wound.read more
Citations
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Journal ArticleDOI
Wound bed preparation: a systematic approach to wound management.
Gregory S. Schultz,R. Gary Sibbald,Vincent Falanga,Elizabeth A. Ayello,Caroline Dowsett,Keith G Harding,Marco Romanelli,Michael Stacey,Luc Téot,Wolfgang Vanscheidt +9 more
TL;DR: Wound bed preparation is the management of a wound in order to accelerate endogenous healing or to facilitate the effectiveness of other therapeutic measures to select the most appropriate intervention.
Journal ArticleDOI
Management of venous leg ulcers: clinical practice guidelines of the Society for Vascular Surgery ® and the American Venous Forum.
Thomas F. O'Donnell,Marc A. Passman,William A. Marston,William J. Ennis,Michael C. Dalsing,Robert L. Kistner,Fedor Lurie,Peter K. Henke,Monika L. Gloviczki,Bo Eklof,Julianne Stoughton,Sesadri Raju,Cynthia K. Shortell,Joseph D. Raffetto,Hugo Partsch,Lori C. Pounds,Mary E. Cummings,David L. Gillespie,Robert B. McLafferty,Mohammad Hassan Murad,Thomas W. Wakefield,Peter Gloviczki +21 more
TL;DR: Thomas F. O'Donnell, MD, Marc A. Passman and Peter K. Gloviczki as mentioned in this paper, MD, PhD, Bo G. Eklof et al.
Journal ArticleDOI
Early healing events in a porcine model of contaminated wounds: effects of nanocrystalline silver on matrix metalloproteinases, cell apoptosis, and healing.
TL;DR: The results suggest that nanocrystalline silver may play a role in altering or compressing the inflammatory events in wounds and facilitating the early phases of wound healing, associated with reduced local matrix metalloproteinase levels and enhanced cellular apoptosis.
Journal ArticleDOI
Silver dressings: their role in wound management.
TL;DR: There are good indications for the use of silver dressings, to remove or reduce an increasing bioburden in burns and open wounds healing by secondary intention, or to act as a barrier against cross contamination of resistant organisms such as MRSA.
Journal ArticleDOI
Molecular markers in patients with chronic wounds to guide surgical debridement.
Harold Brem,Olivera Stojadinovic,Robert F. Diegelmann,Hyacinth Entero,Hyacinth Entero,Brian Lee,Irena Pastar,Michael S. Golinko,Harvey J. Rosenberg,Marjana Tomic-Canic +9 more
TL;DR: It is concluded that chronic ulcers contain distinct subpopulations of cells with different capacity to heal and that gene expression profiling can be utilized to identify them, thereby making surgical debridement more accurate and more efficacious.
References
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Journal ArticleDOI
Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells.
James G. Rheinwatd,Howard Green +1 more
TL;DR: Human diploid epidermis epidermal cells have been successfully grown in serial culture and it is possible to isolate keratinocyte clones free of viable fibroblasts, and human diploids keratinocytes appear to have a finite culture lifetime.
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Formation of the Scab and the Rate of Epithelization of Superficial Wounds in the Skin of the Young Domestic Pig
TL;DR: It has been found that epithelization is retarded by the dry scab which normally covers a superficial wound, and if the formation of the scab is prevented, the rate of epithelized is markedly increased.
Journal ArticleDOI
Functions of hyaluronan in wound repair
TL;DR: The general physicochemical and biological properties of hyaluronan, and how these properties may be utilized in the various processes of wound healing: inflammation, granulation and reepithelization, are presented.
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Validation of a diabetic wound classification system. The contribution of depth, infection, and ischemia to risk of amputation.
TL;DR: Outcomes deteriorated with increasing grade and stage of wounds when measured using the University of Texas Wound Classification System and a significant overall trend toward increased prevalence of amputations was seen.
Journal ArticleDOI
Definitions and Guidelines for Assessment of Wounds and Evaluation of Healing
Gerald S. Lazarus,Diane M. Cooper,David R. Knighton,David J. Margolis,Roger E. Pecoraro,George T. Rodeheaver,Martin C. Robson +6 more
TL;DR: The report that follows defines wound, acute wound, chronic wound, healing and forms of healing, wound assessment, wound extent, wound burden, and wound severity, broadly applicable to all wounds.