Journal ArticleDOI
Probiotics alleviate autoimmune hepatitis in mice through modulation of gut microbiota and intestinal permeability.
Qingqing Liu,Haixia Tian,Yongbo Kang,Yan Tian,Lin Li,Xing Kang,Hao Yang,Yanhong Wang,Jihua Tian,Fan Zhang,Mingwei Tong,Hongyan Cai,Weiping Fan +12 more
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TLDR
In this article, compound probiotic maintained intestinal barrier integrity, blocked lipopolysaccharide (LPS) translocation, and inhibited the activation of TLR4/NF-κB pathway and the production of inflammatory factors in the liver and ileum.Abstract:
Autoimmune hepatitis (AIH) is an immune-mediated type of chronic liver inflammation accompanied by intestinal flora imbalance. Probiotics have been reported to ameliorate imbalances in the intestinal flora. This study aimed to investigate the effects of compound probiotic in the AIH mouse model. AIH mice were gavaged with compound probiotic and injected intraperitoneally with dexamethasone (dex) for 42 days. The results showed that these treatments suppressed hepatic inflammatory cell infiltration, serum transaminase, and Th1 and Th17 cells. However, Treg cells were increased only in the probiotics group, which indicates an immunomodulatory role of the compound probiotic. The compound probiotic maintained intestinal barrier integrity, blocked lipopolysaccharide (LPS) translocation, and inhibited the activation of the TLR4/NF-κB pathway and the production of inflammatory factors in the liver and ileum. Moreover, the compound probiotic treatment increased the abundance of beneficial bacteria and reduced the abundance of potentially harmful bacteria in gut. Compound probiotic may improve ileal barrier function while increasing the diversity of the intestinal flora, blocking the translocation of gut-derived LPS to the liver and therefore preventing activation of the TLR4/NF-κB pathway. The resulting inhibition of pro-inflammatory factor production facilitates AIH remission.read more
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Journal ArticleDOI
Trust Your Gut: The Association of Gut Microbiota and Liver Disease
Ridda Manzoor,Weshah Ahmed,Nariman Afify,Mashal Memon,Maryam Yasin,Hamda Memon,Mohammad Rustom,Mohannad Al Akeel,Noora Alhajri +8 more
TL;DR: The changes seen in the gut microbiome in liver diseases and the association between gut dysbiosis and liver disease are described, and treatment options that may improve gut Dysbiosis in patients with liver diseases are explored.
Journal ArticleDOI
The Role of Gut Microbiota in Some Liver Diseases: From an Immunological Perspective
TL;DR: The role of gut microbiota and its metabolites in the pathogenesis and development of autoimmune liver diseases, metabolic liver disease such as non-alcoholic fatty liver disease, cirrhosisits and its complications, and liver cancer was reviewed from the perspective of immune mechanism.
Journal ArticleDOI
The Gut Microbiota: A Novel Player in Autoimmune Hepatitis
Zilu Cheng,Ling Yang,Huikuan Chu +2 more
TL;DR: The increasing trend of the aerobic bacteria abundance in both AIH patients and AIH mice models is summarized, and the combination of specific bacteria species was found distinct toAIH patients, which could be a promising tool for diagnosing AIH.
Journal ArticleDOI
HLA, gut microbiome and hepatic autoimmunity
TL;DR: Genetic susceptibility to autoimmune liver diseases is conferred mainly by polymorphisms of genes encoding for the human leukocyte antigens (HLA), with the strongest predisposition to autoimmune hepatitis type 1 (AIH-1) linked to the allele DRB1*03:01, possession of which is associated with earlier disease onset and more severe course.
Journal ArticleDOI
Crosstalk between the gut microbiota and postmenopausal osteoporosis: Mechanisms and applications.
TL;DR: In this paper , a review of the relationship between the gut microbiota and postmenopausal osteoporosis (PMO) is presented, which mainly includes the underlying mechanisms between hormones, immunity, nutrient metabolism, metabolites of the Gut microbiota and intestinal permeability.
References
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TL;DR: The aim of this review is to summarize what is known on the effects of probiotic microorganisms on the production of short-chain fatty acids by gut microbes and verified test results confirming the effectiveness of probiotics in human nutrition by modulating SCFAs production by intestinal microbiome are presented.