Processing of collagen based biomaterials and the resulting materials properties.
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TLDR
The technological principles of processing collagen rich tissues down to collagen hydrolysates and the methods to rebuild differently shaped products are given and the effects of the processing steps on the final materials properties are discussed.Abstract:
Collagen, the most abundant extracellular matrix protein in animal kingdom belongs to a family of fibrous proteins, which transfer load in tissues and which provide a highly biocompatible environment for cells. This high biocompatibility makes collagen a perfect biomaterial for implantable medical products and scaffolds for in vitro testing systems. To manufacture collagen based solutions, porous sponges, membranes and threads for surgical and dental purposes or cell culture matrices, collagen rich tissues as skin and tendon of mammals are intensively processed by physical and chemical means. Other tissues such as pericardium and intestine are more gently decellularized while maintaining their complex collagenous architectures. Tissue processing technologies are organized as a series of steps, which are combined in different ways to manufacture structurally versatile materials with varying properties in strength, stability against temperature and enzymatic degradation and cellular response. Complex structures are achieved by combined technologies. Different drying techniques are performed with sterilisation steps and the preparation of porous structures simultaneously. Chemical crosslinking is combined with casting steps as spinning, moulding or additive manufacturing techniques. Important progress is expected by using collagen based bio-inks, which can be formed into 3D structures and combined with live cells. This review will give an overview of the technological principles of processing collagen rich tissues down to collagen hydrolysates and the methods to rebuild differently shaped products. The effects of the processing steps on the final materials properties are discussed especially with regard to the thermal and the physical properties and the susceptibility to enzymatic degradation. These properties are key features for biological and clinical application, handling and metabolization.read more
Citations
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Collagen in Wound Healing.
TL;DR: In this article, the significance of collagen in different biological processes relevant to wound healing is reviewed and a summary of the current literature on the use of collagen-based products in wound care is provided.
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Natural Polymeric Scaffolds in Bone Regeneration
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Fish Collagen: Extraction, Characterization, and Applications for Biomaterials Engineering.
Hafez Jafari,Alberto Lista,Manuela Mafosso Siekapen,Pejman Ghaffari-Bohlouli,Lei Nie,Houman Alimoradi,Amin Shavandi +6 more
TL;DR: An overview of the recent studies on collagen extraction from marine-based materials, in particular fish by-products, and biomaterials engineering and therapeutic applications of marine collagen are presented.
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Selection of Collagen Membranes for Bone Regeneration: A Literature Review
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Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications-A Review.
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