Production of phenolic compounds from Spirulina maxima microalgae and its protective effects
TLDR
In this article, the enhancing process of phenolics synthesis in Spirulina maxima grown in Zarrouk's medium supplemented with different concentration of NaNO3 and/or combined with phenylalanine (L-PA).Abstract:
The purpose of this study was to illustrate the enhancing process of phenolics synthesis in Spirulina maxima grown in Zarrouk’s medium supplemented with different concentration of NaNO3 and/or combined with phenylalanine (L-PA). Also, the protective efficacy of Spirulina polyphenolic (SPP) extracts against CCI4-induced microsomal lipid peroxidation and scavenging of hydroxyl radical formation were performed. The results revealed that the levels of NaNO3 and L-PA in growth medium had positive effects on the production of biomass (34-64 mg/day), total phenolics (4.51-16.96 mg/g d.w) and flavonoids (1.32-5.12 mg/g d.w) contents. The highest levels of these compounds were obtained in Zarrouk’s medium containing 3.77 g/L NaNO3 and 100 mg/L L-PA. The HPLC-DAD profile of all phenolic extracts of Spirulina showed the presence of large numbers of phenolic acids and flavonoids, in variable levels. Gallic, chlorogenic, cinnamic, pinostrobin and p-OH-benzoic were found as the most abundant constituents among different extracts. Polyphenolic of Spirulina exhibited antioxidant effects CCI4-induced lipid peroxidation (inhibition %) in liver homogenate and on DPPH radical scavenging activity (with IC50 values ranged from 23.22 to 35.62 ig/ml), in dose-depended manner. Their protective potential was comparable to that of standard phenolic antioxidants (BHT, BHA and -tocopherol, with IC50 values ranged from 13.22 to 23.62 ig/ml). Thus, S. maxima can be regarded as potent natural sources of nutraceutical and functional ingredients.read more
Citations
More filters
Journal ArticleDOI
Biologically Active Metabolites Synthesized by Microalgae
Michele Greque de Morais,Bruna da Silva Vaz,Etiele Greque de Morais,Jorge Alberto Vieira Costa +3 more
TL;DR: The aim of this review is to discuss bioactive metabolites produced by microalgae for possible applications in the life sciences.
Journal ArticleDOI
Microalgae biomass as an alternative ingredient in cookies: Sensory, physical and chemical properties, antioxidant activity and in vitro digestibility
Ana Paula Batista,Alberto Niccolai,Patrãcia Fradinho,Solange Fragoso,Ivana Bursic,Liliana Rodolfi,Natascia Biondi,Mario R. Tredici,Isabel Sousa,Anabela Raymundo +9 more
TL;DR: Microalgae can be regarded as an alternative and promising food ingredient due to their nutritional composition, richness in bioactive compounds, and because they are considered a sustainable protein source for the future.
Journal ArticleDOI
Therapeutic Potentials of Microalgae in the Treatment of Alzheimer's Disease.
TL;DR: The antioxidant, anticholinesterase activities as well as the inhibitory effects of some bioactive compounds from microalgae extracts on β-amyloid aggregation and neuronal death are discussed extensively.
Journal ArticleDOI
Functional characters evaluation of biscuits sublimated with pure phycocyanin isolated from Spirulina and Spirulina biomass
TL;DR: It could be concluded that functional biscuits had good sensory and nutritional profiles and can be developed as new niche food market.
Journal ArticleDOI
Anticancer effect of the water extract of a commercial Spirulina (Arthrospira platensis) product on the human lung cancer A549 cell line.
Arkadiusz Czerwonka,Katarzyna Kaławaj,Adrianna Sławińska-Brych,Marta Kinga Lemieszek,Magdalena Bartnik,Krzysztof Kamil Wojtanowski,Barbara Zdzisińska,Wojciech Rzeski +7 more
TL;DR: Evidence of the anti-cancer activity of the commercial Spirulina product against lung cancer cells is provided and the knowledge of the chemopreventive properties of Spiruline is strongly supported.
References
More filters
Journal ArticleDOI
Protective effect of Spirulina against doxorubicin-induced cardiotoxicity.
Mahmood Khan,Mahmood Khan,J. C. Shobha,Iyyapu Krishna Mohan,Madireddi U. Naidu,Challa Sundaram,Shashi Singh,Periannan Kuppusamy,Vijay Kumar Kutala,Vijay Kumar Kutala +9 more
TL;DR: Pretreatment with Spirulina significantly protected mice from DOX‐induced cardiotoxic effects as evidenced from lower mortality, less ascites, lower levels of lipid peroxidation, normalization of antioxidant enzymes and ultrastructural studies showing minimal damage to the heart.
Journal ArticleDOI
Mechanism of early carbon tetrachloride toxicity in cultured rat hepatocytes
TL;DR: It is found that primary rat hepatocytes in culture were killed after a 2 hr incubation with carbon tetrachloride gas at CCl4 partial pressures above a threshold between 45 and 54 mmHg, and below this threshold concentration no increase in hepatocyte death was observed.
Journal ArticleDOI
Urinary tea polyphenols in relation to gastric and esophageal cancers: a prospective study of men in Shanghai, China
TL;DR: There is direct evidence that tea polyphenols may act as chemopreventive agents against gastric and esophageal cancer development and protective effect was primarily seen among subjects with low (below population median) serum carotenes.
Journal ArticleDOI
The suppression of the N-nitrosating reaction by chlorogenic acid.
TL;DR: The observations showed that the mechanism by which chlorogenic acid inhibited N-nitrosation of 2,3-diamino-naphthalene is due to its ability to scavenge the nitrosating agent, nitrogen sesquioxide.
Journal ArticleDOI
Developmental stimulation of total phenolics and related antioxidant activity in light- and dark-germinated corn by natural elicitors
Reena Randhir,Kalidas Shetty +1 more
TL;DR: This study supports the developmental and partial short-term influence of elicitors on the pentose phosphate pathway (PPP), and its mobilization of enhanced phenolics and antioxidant activity.