Journal ArticleDOI
Protection against peripheral artery disease injury by Ruan Jian Qing Mai formula via metabolic programming.
Jian Chen,Zhi-Qiang Liang,Can Hu,Yuan Gao,Yong-kui Wang,Jiang-wei Yang,Cheng Zhao,Ye-min Cao,Cao Yongbing +8 more
TLDR
RJQM has a protection effect on PAD by regulating a complex molecular network associated with the regulation of OXPHOS by 10 active components, which may alleviate mitochondrial dysfunction and pathological metabolic programming.Abstract:
Ruan Jian Qing Mai formula (RJQM), a multicomponent herbal formula, has been widely used to treat peripheral arterial disease (PAD) in China. However, its active compounds and mechanisms of action are still unknown. First, RNA sequencing analysis of 15 healthy and 16 PAD samples showed that 524 PAD differential genes were significantly enriched in Go Ontology (ribonucleotide metabolic process, oxidoreductase complex, and electron transfer activity), Kyoto Encyclopedia of Genes and Genomes (KEGG) and GSEA pathways (OXPHOS and TCA cycle), miRNA (MIR183), and kinase (PAK6). Fifty-three active ingredients in RJQM had similar structures to the seven drug molecules in CLUE. Then, network topology analysis of the 53 components-target-pathway-disease network yielded 10 active ingredients. Finally, computational toxicity estimations showed that the median lethal dose (LD50) of the 10 active ingredients was above 1000 mg/kg, and eight of them did not cause hepatotoxicity, mutagenicity, carcinogenicity, cytotoxicity, and immunotoxicity nor activate 12 toxic pathways. In conclusion, RJQM has a protection effect on PAD by regulating a complex molecular network. Part of the mechanism is associated with the regulation of OXPHOS by 10 active components, which may alleviate mitochondrial dysfunction and pathological metabolic programming.read more
Citations
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Protection against COVID-19 injury by qingfei paidu decoction via anti-viral, anti-inflammatory activity and metabolic programming.
Jian Chen,Yong-kui Wang,Yuan Gao,Ling-San Hu,Jiang-wei Yang,Jian-ru Wang,Wen-jie Sun,Zhi-Qiang Liang,Ye-min Cao,Cao Yongbing +9 more
TL;DR: QFPD had a protection effect on COVID-19 by regulating a complex molecular network with safety and efficacy, and part of the mechanism was associated with the regulation of anti-viral, anti-inflammatory activity and metabolic programming.
Journal ArticleDOI
Ruan Jian Qing Mai Recipe Inhibits the Inflammatory Response in Acute Lower Limb Ischemic Mice through the JAK2/STAT3 Pathway
Dirui Zhu,Chenglin Jia,Tongkai Cai,Jia-Cheng Li,Xiangyu Feng,Nan Chen,Cheng Zhao,Yuzheng Wang,Yong-Bing Cao,Ye-min Cao +9 more
TL;DR: RJQM can effectively alleviate ASO and promote the recovery of lower limb blood flow by regulating the JAK2/STAT3 signaling pathway to reduce the inflammatory response.
Journal ArticleDOI
Investigation of the mechanisms and experimental verification of Shao yao gan cao decoction against Sphincter of Oddi Dysfunction via systems pharmacology.
TL;DR: This study demonstrates that SYGC confers therapeutic effects against an experimental model of SOD via regulating immune response and inflammation, which provides a basis for future research and clinical applications.
Ruan JianQingMaiRecipe Inhibits the InflammatoryResponse in Acute Lower Limb Ischemic Mice through the JAK2/ STAT3 Pathway
Dirui Zhu,Chenglin Jia,Tongkai Cai,Jiacheng Li,Xiangyu Feng,Nan Chen,Cheng Zhao,Yuzheng Wang,Yongbing Cao,Ye-min Cao +9 more
TL;DR: This poster presents a probabilistic procedure to correct the abnormality in the response of the central nervous system to certain types of blood clotting disorders.
Journal ArticleDOI
Effect of the Ruan Jian Qing Mai recipe on wound healing in diabetic mice and prediction of its potential targets.
TL;DR: It is proved that the drug could treat diabetic skin damage by activating the PI3K-Akt-VEGF signaling pathway and exerts a good therapeutic effect on diabetic skin wound healing.
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