Protection by inosine in a cellular model of Parkinson's disease.
TLDR
Conditioned medium experiments indicated that the protective effect of inosine relies on the release of a protective factor from inOSine-stimulated astrocytes, and raised the possibility that inosines might have a protective effect in PD that is independent of any effects mediated through its metabolite urate.About:
This article is published in Neuroscience.The article was published on 2014-08-22 and is currently open access. It has received 29 citations till now. The article focuses on the topics: Inosine & Hypoxanthine.read more
Citations
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Targeting urate to reduce oxidative stress in Parkinson disease.
TL;DR: In this paper, the main antioxidant found in plasma as well as the end product of purine metabolism in humans, has emerged as a promising potential neuroprotectant with advantages that distinguish it from previously tested antioxidant agents.
Journal ArticleDOI
Urate and Its Transgenic Depletion Modulate Neuronal Vulnerability in a Cellular Model of Parkinson's Disease
Sara Cipriani,Cody A. Desjardins,Thomas C. Burdett,Yuehang Xu,Kui Xu,Michael A. Schwarzschild +5 more
TL;DR: The findings correlate intracellular urate content in dopaminergic neurons with their toxin resistance in a cellular model of PD and suggest a facilitative role for astrocytes in the neuroprotective effect of urate.
Journal ArticleDOI
Inosine improves cognitive function and decreases aging-induced oxidative stress and neuroinflammation in aged female rats.
Poonam Ruhal,Dinesh Dhingra +1 more
TL;DR: In conclusion, inosine significantly improved learning and memory of aged female rats possibly through its antioxidant as well as anti-inflammatory effect and improvement of neuronal survival in the hippocampal CA1 region.
Journal ArticleDOI
Oral Inosine Persistently Elevates Plasma antioxidant capacity in Parkinson's disease.
Shamik Bhattacharyya,Shamik Bhattacharyya,Rachit Bakshi,Robert Logan,Alberto Ascherio,Eric A. Macklin,Michael A. Schwarzschild +6 more
TL;DR: Higher serum urate predicts slower progression in PD and oral inosine alters antioxidant capacity of plasma or CSF or urinary markers of oxidative injury in early PD.
Journal ArticleDOI
Inosine - a Multifunctional Treatment for Complications of Neurologic Injury.
Claire Doyle,Claire Doyle,Vivian Cristofaro,Vivian Cristofaro,Vivian Cristofaro,Maryrose P. Sullivan,Maryrose P. Sullivan,Maryrose P. Sullivan,Rosalyn M. Adam,Rosalyn M. Adam +9 more
TL;DR: Experimental evidence suggests inosine is a safe, novel agent with multifunctional properties that is effective in treating complications of SCI and other neuropathies.
References
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Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill
TL;DR: It was shown that phenol red does not interfere with the measurements and no washing steps are required since all ingredients can be added subsequently, and Serum proteins at concentrations up to 25% have no influence on the result.
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Plasma Urate and Risk of Parkinson's Disease
TL;DR: It is suggested that high plasma urate concentrations may decrease the risk of Parkinson's disease, and the possibility that interventions to increase Plasma urate may reduce the risk and delay the progression of Parkinson’s disease is raised.
Journal ArticleDOI
Urate as a predictor of the rate of clinical decline in Parkinson disease.
Alberto Ascherio,Peter A. LeWitt,Kui Xu,Shirley Eberly,Arthur Watts,Wayne R. Matson,Connie Marras,Karl Kieburtz,Alice Rudolph,Mikhail B. Bogdanov,Steven R. Schwid,Marsha Tennis,Caroline M. Tanner,M. Flint Beal,Anthony E. Lang,David Oakes,Stanley Fahn,Ira Shoulson,Michael A. Schwarzschild +18 more
TL;DR: Higher serum and cerebrospinal fluid urate concentrations at baseline were associated with slower rates of clinical decline and the link between urate concentration and PD is strengthened and the rationale for considering central nervous system urATE concentration elevation as a potential strategy to slow PD progression is strengthened.
Journal ArticleDOI
Inosine Inhibits Inflammatory Cytokine Production by a Posttranscriptional Mechanism and Protects Against Endotoxin-Induced Shock
György Haskó,David G. Kuhel,Zoltán Németh,Jon G. Mabley,Robert F. Stachlewitz,László Virág,Zsolt Lohinai,Garry J. Southan,Andrew L. Salzman,Csaba Szabó +9 more
TL;DR: Inosine suppressed proinflammatory cytokine production and mortality in a mouse endotoxemic model and suggests that this agent may be useful in the treatment of inflammatory/ischemic diseases.
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