Proteogenomic Assessment of Intraspecific Venom Variability: Molecular Adaptations in the Venom Arsenal of Conus purpurascens.
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TLDR
In this paper, the authors employ a proteogenomic approach to maximize conopeptide identification from the injected venom of Conus purpurascens, which reveals two distinct venom profiles with different synergistic interactions to effectively target neural pathways aimed to immobilize prey.About:
This article is published in Molecular & Cellular Proteomics.The article was published on 2021-01-01 and is currently open access. It has received 5 citations till now. The article focuses on the topics: Conus purpurascens & Venom.read more
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Bee core venom genes predominantly originated before aculeate stingers evolved
Ivan Koludarov,Mariana Velasque,Thomas Timm,Guenter Lochnit,Michael Heinzinger,Andreas Vilcinskas,Rosalyn Gloag,Brock A. Harpur,Lars Podsiadlowski,Burkhard Rost,Sébastien Dutertre,Eckart Stolle,Bjoern Marcus von Reumont +12 more
TL;DR: In this paper , the authors combined proteo-transcriptomics with comparative genomics compiling an up-to-date list of core bee venom proteins to investigate the origin of 11 venom genes in 30 hymenopteran genomes including two newly sequenced genomes of stingless bees.
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Comparative Venomics of the Cryptic Cone Snail Species Virroconus ebraeus and Virroconus judaeus
TL;DR: The 3D structure model of selected venom proteins including the differentially expressed Cerm03 and SF-mi2, an insulin type 3, a Gastridium geographus GVIA-like conotoxin, and an ortholog to the Pionoconus magus ω-conotoxin MVIIA (Ziconotide) are predicted.
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A common venomous ancestor? Prevalent bee venom genes evolved before the aculeate stinger while few major toxins are bee-specific
Ivan Koludarov,Mariana Velasque,Thomas Timm,Carola Greve,Alexander Ben Hamadou,Deepak K. Gupta,Günter Lochnit,Michael Heinzinger,Andreas Vilcinskas,Rosalyn Gloag,Brock A. Harpur,Lars Podsiadlowski,Burkhard Rost,Timothy N.W. Jackson,Sébastien Dutertre,Eckart Stolle,Björn M. von Reumont +16 more
TL;DR: In this paper , the authors investigated the origin of 11 toxin genes in 29 published and three new hymenopteran genomes and compiled an up-to-date list of prevalent bee venom proteins.
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Comparative Venomics of C. flavidus and C. frigidus and Closely Related Vermivorous Cone Snails
TL;DR: Investigating the venom of two phylogenetically and spatially related species suggests rapid conotoxin sequence divergence may have facilitated adaptive radiation and the establishment of new species and the regulatory mechanisms facilitating species-specific venom evolution.
References
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