Journal ArticleDOI
Proton Pump Inhibitors Exacerbate NSAID-Induced Small Intestinal Injury by Inducing Dysbiosis
John L. Wallace,Stephanie D. Syer,Emmanuel Denou,Giada De Palma,Linda Vong,Webb McKnight,Jennifer Jury,Manlio Bolla,Premysl Bercik,Stephen M. Collins,Elena F. Verdu,Ennio Ongini +11 more
TLDR
PPIs exacerbate NSAID-induced intestinal damage at least in part because of significant shifts in enteric microbial populations, and prevention or reversal of this dysbiosis may be a viable option for reducing the incidence and severity of NSAID enteropathy.About:
This article is published in Gastroenterology.The article was published on 2011-10-01. It has received 395 citations till now. The article focuses on the topics: Proton-pump inhibitor & Dysbiosis.read more
Citations
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Journal ArticleDOI
The intestinal barrier: a fundamental role in health and disease.
TL;DR: The anatomy of the intestinal barrier is discussed and the available methods to evaluate its function are explained, which may improve the current understanding of the gut barrier, and provide a step forward towards personalised medicine.
Journal ArticleDOI
Mechanisms of inflammation-driven bacterial dysbiosis in the gut.
TL;DR: Summary of studies that examined factors in the inflamed gut that contribute to blooms of Enterobacterieaceae, and potential approaches to restrict Enterobacterial blooms in treating diseases that are otherwise complicated by overgrowth of virulent Enterob bacterial species in the gut are highlighted.
Journal ArticleDOI
Mechanisms of Damage to the Gastrointestinal Tract From Nonsteroidal Anti-Inflammatory Drugs
Ingvar Bjarnason,Carmelo Scarpignato,Erik Holmgren,Michael Olszewski,Kim D. Rainsford,Angel Lanas +5 more
TL;DR: A model for NSAID-induced damage to the gastrointestinal tract is proposed that includes these complex, interacting, and inter-dependent factors and highlights the obstacles for the development of safer NSAIDs.
Journal ArticleDOI
The influence of non-steroidal anti-inflammatory drugs on the gut microbiome
TL;DR: Bacteria in the gastrointestinal tract reflect the combinations of medications that people ingest, and the bacterial composition of the gut varied with the type of NSAID ingested.
Journal ArticleDOI
Risk of Upper and Lower Gastrointestinal Bleeding in Patients Taking Nonsteroidal Anti-inflammatory Drugs, Antiplatelet Agents, or Anticoagulants
Angel Lanas,Patricia Carrera-Lasfuentes,Yolanda Arguedas,Santiago García,Luis Bujanda,Xavier Calvet,Julio Ponce,Ángeles Pérez-Aisa,Manuel Castro,María Jesús Muñoz,Carlos Sostres,Luis A García-Rodríguez +11 more
TL;DR: Anticoagulants, low-dose aspirin, NSAIDs, and other non-aspirin-APA drugs are associated with increased risk of upper and lower gastrointestinal bleeding and use of anticoagULants appears to be the strongest risk factor for gastrointestinal bleeding.
References
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Nucleotide sequence of bacteriophage G4 DNA.
TL;DR: The sequence identifies many of the features responsible for the production of the proteins of the nine known genes of the organism, including initiation and termination sites for the proteins and RNAs.
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Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans
TL;DR: The adverse effects of NSAIDs distal to the duodenum represent a range of pathologies that may be asymptomatic, but some are life threatening.
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A Comparison of Omeprazole with Ranitidine for Ulcers Associated with Nonsteroidal Antiinflammatory Drugs
Neville D. Yeomans,Zsolt Tulassay,L. Juhasz,I. Racz,J M Howard,C. J. Van Rensburg,A J Swannell,Christopher J. Hawkey +7 more
TL;DR: In patients with regular use of NSAIDs, omeprazole healed and prevented ulcers more effectively than did ranitidine.
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NSAID-induced gastric damage in rats: Requirement for inhibition of both cyclooxygenase 1 and 2
TL;DR: Inhibition of both COX-1 andCOX-2 is required for NSAID-induced gastric injury in the rat, and the combination of SC-560 and celecoxib invariably caused hemorrhagic erosion formation, comparable to that seen with indomethacin.
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Analysis of the fecal microflora of human subjects consuming a probiotic product containing Lactobacillus rhamnosus DR20.
TL;DR: It is concluded that consumption of the DR20-containing milk product transiently altered the Lactobacillus and enterococcal contents of the feces of the majority of consumers without markedly affecting biochemical or other bacteriological factors.