Pseudomonas aeruginosa Exotoxin Y Is a Promiscuous Cyclase That Increases Endothelial Tau Phosphorylation and Permeability
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TLDR
ExoY is a promiscuous cyclase and edema factor that uses cAMP and, to some extent, cGMP to induce the hyperphosphorylation and insolubility of endothelial Tau.About:
This article is published in Journal of Biological Chemistry.The article was published on 2012-07-20 and is currently open access. It has received 89 citations till now. The article focuses on the topics: Cyclase & Phosphorylation.read more
Citations
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Familial multiple system tauopathy with presenile dementia: A disease with abundant neuronal and glial tau filaments (microtubule-associated protein tauyfamilial disease)
TL;DR: In this paper, a novel autosomal dominant disease named familial ''multiple system tauopathy with presenile dementia'' was described, which is charac- terized by abundant fibrillary deposits of tau protein in both neurons and glial cells.
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Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy
Laura J. Blair,Haley D Frauen,Bo Zhang,Bryce A. Nordhues,Sara Bijan,Yen-Chi Lin,Frank Zamudio,Lidice D Hernandez,Jonathan J. Sabbagh,Maj-Linda B. Selenica,Chad A. Dickey +10 more
TL;DR: For the first time, data demonstrate that tau alone can initiate breakdown of the blood-brain barrier, but the BBB is remarkably resilient, maintaining its integrity in the face of marked brain atrophy, neuroinflammation and toxic tau accumulation.
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The molecular mechanism of acute lung injury caused by Pseudomonas aeruginosa: from bacterial pathogenesis to host response
TL;DR: Blockade of translocation by TTSS or inhibition of the enzymatic activity of translocated toxins has the potential to decrease acute lung injury and improve clinical outcome.
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Pneumonia-induced endothelial amyloids reduce dendritic spine density in brain neurons.
Allison M. Scott,Alexandrea C. Jager,M.S. Gwin,S.B. Voth,Ron Balczon,Troy Stevens,Mike T. Lin +6 more
TL;DR: It is indicated that infection-elicited lung endothelial amyloids are neurotropic and reduce neuronal dendritic spine density in vivo and cause injury to neuronal structure.
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Pitfalls in assessing microvascular endothelial barrier function: impedance-based devices versus the classic macromolecular tracer assay.
Iris Bischoff,Michael C. Hornburger,Bettina A. Mayer,Andrea Beyerle,Joachim Wegener,Robert Fürst +5 more
TL;DR: The first direct comparison of these assays applied to one single cell type (human microvascular ECs) under the same experimental conditions concludes that the complementary combination of both approaches is highly recommended to overcome the restrictions of each assay.
References
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Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension.
TL;DR: Gene splicing by overlap extension is a new approach for recombining DNA molecules at precise junctions irrespective of nucleotide sequences at the recombination site and without the use of restriction endonucleases or ligase.
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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
Inge Grundke-Iqbal,Khalid Iqbal,Yunn-Chyn Tung,Maureen Quinlan,Henryk M. Wisniewski,Lester I. Binder +5 more
TL;DR: It is suggested that tau in Alzheimer brain is an abnormally phosphorylated protein component of PHF, the two major locations of paired-helical filaments in Alzheimer disease brain.
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Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.
TL;DR: Both the holoenzyme and the catalytic subunit (or fragment), which is active without an enzyme activator, are susceptible to these compounds with a similar concentration dependency, thereby indicating that the inhibitory effect is attributed to the direct interaction of the compound with the active center of the enzyme but not with the enzymeactivator.
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Signaling Mechanisms Regulating Endothelial Permeability
Dolly Mehta,Asrar B. Malik +1 more
TL;DR: This review summarizes and analyzes the recent data from genetic, physiological, cellular, and morphological studies that have addressed the signaling mechanisms involved in the regulation of both the paracellular and transcellular transport pathways.
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K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases
Hiroshi Kase,Kazuyuki Iwahashi,Satoshi Nakanishi,Yuzuru Matsuda,Koji Yamada,Mitsuru Takahashi,Chikara C O Patent De Murakata,Akira Sato,Masami Kaneko +8 more
TL;DR: K-252a was a non-selective inhibitor for these three protein kinases with Ki values 18-25 nM, whereas K-252b showed a comparable potency for protein kinase C (Ki, 20nM), whereas inhibitory potencies for cyclic nucleotide-dependentprotein kinases were reduced.