Journal ArticleDOI
Pulsatile non-Newtonian blood flow in three-dimensional carotid bifurcation models: a numerical study of flow phenomena under different bifurcation angles.
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TLDR
The results show that the complex flow in the sinus is affected by the angle variation, and the haemodynamic phenomena, which are important in atherogenesis, are more pronounced in the large angle bifurcation.About:
This article is published in Journal of Biomedical Engineering.The article was published on 1991-11-01. It has received 211 citations till now. The article focuses on the topics: Pulsatile flow & Navier–Stokes equations.read more
Citations
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Journal ArticleDOI
Finite element modeling of blood flow in arteries
TL;DR: The software system developed provides an integrated set of tools to solve clinically relevant blood flow problems and test hypotheses regarding hemodynamic factors in vascular adaptation and disease and the validity of the computational method was established.
Journal ArticleDOI
Computer simulation of local blood flow and vessel mechanics in a compliant carotid artery bifurcation model
Karl Perktold,Gerhard Rappitsch +1 more
TL;DR: A numerical model for the blood flow in the human carotid artery bifurcation has been developed and the comparison of the results for a rigid and a distensible wall model demonstrates quantitative influence of the vessel wall motion.
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The influence of the non-Newtonian properties of blood on the flow in large arteries: steady flow in a carotid bifurcation model.
TL;DR: In the computations, the shear thinning behavior of the analog blood fluid was incorporated through the Carreau-Yasuda model, and this seems to be the dominant non-Newtonian property of the blood analog fluid under steady flow conditions.
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Residual strain effects on the stress field in a thick wall finite element model of the human carotid bifurcation.
TL;DR: The results suggest that the localization of atherosclerosis in the carotid artery may be due to local variations in both fluid wall shear stress and solid wall stress.
Journal ArticleDOI
Hemodynamics of Cerebral Aneurysms.
TL;DR: Recent progress on the basic mechanisms of aneurysm formation and evolution are reviewed, with a focus on the role of hemodynamic patterns.
References
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Journal ArticleDOI
Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress.
TL;DR: These studies confirm earlier findings under steady flow conditions that plaques tend to form in areas of low, rather than high, shear stress, but indicate in addition that marked oscillations in the direction of wall shear may enhance atherogenesis.
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Carotid bifurcation atherosclerosis. Quantitative correlation of plaque localization with flow velocity profiles and wall shear stress.
Christopher K. Zarins,Don P. Giddens,B. K. Bharadvaj,V S Sottiurai,R.F. Mabon,Seymour Glagov +5 more
TL;DR: It is concluded that in the human carotid bifurcation, regions of moderate to high shear stress, where flow remains unidirectional and axially aligned, are relatively spared of intimal thickening.
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Atheroma and arterial wall shear. Observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis.
TL;DR: It appears that wall shear rate may be a major controlling factor in the development of atheromatous lesions in man and in animals and a net flux of cholesterol from blood to wall cannot account for the observed normally occurring (quasi-steady state) and experimentally induced atheroma.
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Steady flow in a model of the human carotid bifurcation. Part I--flow visualization.
TL;DR: Comparison with pathologic data on localization of atherosclerotic lesions indicates that zones susceptible to disease experience low or oscillatory shear stress while regions subject to higher shear are free of deposits.
Journal ArticleDOI
Pulsatile Non-Newtonian Flow Characteristics in a Three-Dimensional Human Carotid Bifurcation Model
TL;DR: The investigation shows complex flow patterns especially in the carotid sinus where flow separation occurs at the outer wall throughout the systolic deceleration phase and the changing sign of the velocity near the outer sinus wall results in oscillating shear stress during the pulse cycle.