Journal ArticleDOI
Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation
P. E. Vermeulen,Giampietro Gasparini,Stephen B. Fox,Masakazu Toi,L. Martin,Peter McCulloch,Francesco Pezzella,Giuseppe Viale,Noel Weidner,Adrian L. Harris,Luc Dirix +10 more
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‘Angiogenesis Group, Department of Oncology, Antwerp University Hospital, Wilrijkstraat 10, B-2650 Edegem, Belgium'; ‘ICRF Molecular Oncologists, University of Oxford, Oxford, U.K.About:
This article is published in European Journal of Cancer.The article was published on 1996-12-01. It has received 758 citations till now.read more
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Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999.
Carolyn C. Compton,L. Peter Fielding,Lawrence J. Burgart,Barbara A. Conley,Harry S. Cooper,Stanley R. Hamilton,M. Elizabeth H. Hammond,Donald E. Henson,Robert V. P. Hutter,Raymond B. Nagle,Mary L. Nielsen,Daniel J. Sargent,Clive R. Taylor,Mark L. Welton,Christopher G. Willett +14 more
TL;DR: The current state of knowledge regarding pathologic prognostic factors and predictive factors in colorectal carcinoma was evaluated and recommendations were made to increase the uniformity and completeness of pathologic evaluation of tumor specimens and to improve patient care.
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Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes
Alvaro Aguayo,Hagop M. Kantarjian,Taghi Manshouri,Cristi Gidel,Elihu H. Estey,Deborah A. Thomas,Charles Koller,Zeev Estrov,Susan O'Brien,Michael J. Keating,Emil J. Freireich,Maher Albitar +11 more
TL;DR: The data suggest that vascularity and angiogenic factors are increased in leukemias and MDS and may play a role in theLeukemogenic process.
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Vasculogenic Mimicry and Tumor Angiogenesis
TL;DR: The unique patterning characteristic of vasculogenic mimicry provides an opportunity to design noninvasive imaging techniques to detect highly aggressive neoplasms and their metastases.
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Vascular Endothelial Growth Factor (VEGF)-Mediated Angiogenesis Is Associated with Enhanced Endothelial Cell Survival and Induction of Bcl-2 Expression
TL;DR: Results suggest that the angiogenic activity attributed to VEGF may be due in part to its ability to enhance endothelial cell survival by inducing expression of the anti-apoptotic protein Bcl-2.
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CD105 is important for angiogenesis: evidence and potential applications.
TL;DR: CD105 is a promising vascular target that can be used for tumor imaging, prognosis, and bears therapeutic potential in patients with solid tumors and other angiogenic diseases.
References
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Angiogenesis in cancer, vascular, rheumatoid and other disease
TL;DR: Think of the switch to the angiogenic phenotype as a net balance of positive and negative regulators of blood vessel growth, which may dictate whether a primary tumour grows rapidly or slowly and whether metastases grow at all.
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Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.
TL;DR: The number of microvessels per 200x field in the areas of most intensive neovascularization in an invasive breast carcinoma may be an independent predictor of metastatic disease either in axillary lymph nodes or at distant sites (or both).
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What is the evidence that tumors are angiogenesis dependent
TL;DR: Method of treating a wound or burn which comprises directly dressing its surface with non-woven fabric comprising staple fibers of spun, regenerated collagen substantially free of telopeptides is disclosed.
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Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis.
TL;DR: It is shown that vascular endothelial growth factor (VEGF) probably functions as a hypoxia-inducible angiogenic factor and is specifically induced in a subset of glioblastoma cells distinguished by their immediate proximity to necrotic foci and the clustering of capillaries alongside VEGF-producing cells.
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Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis.
TL;DR: The realization that tumor growth requires new blood vessels and the identification of chemical factors that mediate angiogenesis have broadened the understanding of pathologic processes and opened new avenues to the diagnosis and treatment of these diseases.