Journal ArticleDOI
Quantitative NMR spectroscopy in pharmaceutical applications.
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In this article, the authors proposed a method to solve the problem of "missing links" in the context of biomedical data. But they did not specify how to find them. ButAbout:
This article is published in Progress in Nuclear Magnetic Resonance Spectroscopy.The article was published on 2010-05-08. It has received 269 citations till now. The article focuses on the topics: Fluorine-19 NMR.read more
Citations
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Quantitative 1H NMR. Development and Potential of an Analytical Method: An Update
TL;DR: This updated review summarizes a wealth of detailed experiential evidence and newly developed methodology that supports qHNMR as a valuable and unbiased analytical tool for natural product and other areas of research.
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Universal quantitative NMR analysis of complex natural samples
TL;DR: qNMR has become the method of choice for metabolomic studies and quality control of complex natural samples such as foods, plants or herbal remedies, and biofluids and has increased considerably.
Journal ArticleDOI
Dissolution and precipitation behavior of amorphous solid dispersions.
TL;DR: The supersaturation generated upon dissolution of the solid dispersions was maintained for biologically relevant timeframes for the HPMC dispersions, whereas PVP appeared to be a less effective crystallization inhibitor.
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Ultrafast 2D NMR: An Emerging Tool in Analytical Spectroscopy
Patrick Giraudeau,Lucio Frydman +1 more
TL;DR: This review summarizes the principles and main developments that have contributed to the success of the so-called ultrafast (UF) 2D NMR methodology and focuses on applications that have been recently demonstrated in various areas of analytical chemistry.
Journal ArticleDOI
NMR techniques in biomedical and pharmaceutical analysis.
TL;DR: The first part of this article presents an overview of the advantages and limitations of NMR for in vitro quantitative analysis of complex matrices in liquid or semi-solid phases and describes the in vivo clinical magnetic resonance spectroscopy techniques.
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Journal ArticleDOI
NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities.
TL;DR: 1H and 13C chemical shifts of what are, in the authors' experience, the most popular “extra peaks” in a variety of commonly used NMR solvents are collected, in the hope that this will be of assistance to the practicing chemist.
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Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts.
Olaf Beckonert,Hector C. Keun,Timothy M. D. Ebbels,Jacob G. Bundy,Elaine Holmes,John C. Lindon,Jeremy K. Nicholson +6 more
TL;DR: The main NMR spectroscopic applications in modern metabolic research are summarized, and detailed protocols for biofluid and tissue sample collection and preparation are provided, including the extraction of polar and lipophilic metabolites from tissues.
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Contaminated heparin associated with adverse clinical events and activation of the contact system.
Takashi Kei Kishimoto,Karthik Viswanathan,Tanmoy Ganguly,Subbiah Elankumaran,Sean W. Smith,Kevin D. Pelzer,Jonathan C. Lansing,Nammalwar Sriranganathan,Ganlin Zhao,Zoya Galcheva-Gargova,Ali Al-Hakim,Gregory Scott Bailey,Blair A. Fraser,Sucharita Roy,Thomas Rogers-Cotrone,Lucinda F. Buhse,Mark T. Whary,James G. Fox,Moheb Nasr,Gerald J. Dal Pan,Zachary Shriver,Robert Langer,Ganesh Venkataraman,K. Frank Austen,Janet Woodcock,Ram Sasisekharan +25 more
TL;DR: An assay to assess the amidolytic activity of kallikrein can supplement analytic tests to protect the heparin supply chain by screening for OSCS and other highly sulfated polysaccharide contaminants of hepar in that can activate the contact system.
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Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events.
Marco Guerrini,Daniela Beccati,Zachary Shriver,Annamaria Naggi,Karthik Viswanathan,Antonella Bisio,Ishan Capila,Jonathan C. Lansing,Sara Guglieri,Blair A. Fraser,Ali Al-Hakim,Nur Sibel Gunay,Zhenqing Zhang,Luke Robinson,Lucinda F. Buhse,Moheb Nasr,Janet Woodcock,Robert Langer,Ganesh Venkataraman,Robert J. Linhardt,Benito Casu,Giangiacomo Torri,Ram Sasisekharan +22 more
TL;DR: Through detailed structural analysis, the contaminant was found to contain a disaccharide repeat unit of glucuronic acid linked β1→3 to a β-N-acetylgalactosamine, indicative of an allergic-type reaction.
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Validation of quantitative NMR.
TL;DR: A validated protocol for quantitative high resolution 1H-NMR using single pulse excitation that considers all issues regarding linearity, robustness, specificity, selectivity and accuracy as well as influences of instrument specific parameters and the data processing and evaluation routines is described.