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Recent advances in copper-catalysed radical-involved asymmetric 1,2-difunctionalization of alkenes
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This tutorial review highlights the recent progress in copper-catalysed radical-involved asymmetric 1,2-difunctionalization of alkenes and the mechanistic scenarios governing the stereocontrol, with an emphasis on utilization of chiral ligands.Abstract:
The radical-involved 1,2-difunctionalization of alkenes has developed into a robust tool for preparation of complex organic molecules. Despite significant advances in this area, the catalytic asymmetric version still remains a challenging task mainly due to the difficulty in the stereocontrol of the highly reactive radical intermediates. Recently, owing to the good single-electron transfer ability and coordination with chiral ligands of copper catalysts, remarkable achievements in radical-involved asymmetric alkene difunctionalization have been made via synergistic combination of copper and chiral ligands. This tutorial review highlights the recent progress in copper-catalysed radical-involved asymmetric 1,2-difunctionalization of alkenes and the mechanistic scenarios governing the stereocontrol, with an emphasis on utilization of chiral ligands.read more
Citations
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References
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Journal ArticleDOI
Photoredox Catalysis in Organic Chemistry
TL;DR: This Perspective highlights the unique ability of photoredox catalysis to expedite the development of completely new reaction mechanisms, with particular emphasis placed on multicatalytic strategies that enable the construction of challenging carbon-carbon and carbon-heteroatom bonds.
Journal ArticleDOI
Copper Active Sites in Biology
Edward I. Solomon,David E. Heppner,Esther M. Johnston,Jake W. Ginsbach,Jordi Cirera,Munzarin F. Qayyum,Matthew T. Kieber-Emmons,Christian H. Kjaergaard,Ryan G. Hadt,Li Tian +9 more
TL;DR: This review presents in depth discussions of all these classes of Cu enzymes and the correlations within and among these classes, as well as the present understanding of the enzymology, kinetics, geometric structures, electronic structures and the reaction mechanisms these have elucidated.
Journal ArticleDOI
Addition of CF3 across unsaturated moieties: a powerful functionalization tool
Estíbaliz Merino,Cristina Nevado +1 more
TL;DR: This review summarizes recent methodologies for the simultaneous formation of C–CF3 and C–C or C–heteroatom bonds by formal addition reactions to alkenes.
Journal ArticleDOI
Radicals: Reactive Intermediates with Translational Potential
TL;DR: This Perspective illustrates the defining characteristics of free radical chemistry, beginning with its rich and storied history, and studies from the laboratory are discussed along with recent developments emanating from others in this burgeoning area.
Journal ArticleDOI
Transition metal-catalyzed alkyl-alkyl bond formation: Another dimension in cross-coupling chemistry.
Junwon Choi,Gregory C. Fu +1 more
TL;DR: Recent developments in forming bonds between the more abundant alkyl carbon centers that underlie diverse molecules with complex three-dimensional structures are reviewed, with a number of major challenges remain.
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