Recent Challenges in Insulin Delivery Systems: A Review
TLDR
The inhalation delivery system Exubera® has already become clinically available in the United States and Europe for patients with diabetes as non-invasive delivery system.Abstract:
Relatively, a large percentage of world population is affected by diabetes mellitus, out of which approximately 5-10% with type 1 diabetes while the remaining 90% with type 2 Insulin administration is essential for type 1 patients while it is required at later stage by the patients of type 2 Current insulin delivery systems are available as transdermal injections which may be considered as invasive Several non-invasive approaches for insulin delivery are being pursued by pharmaceutical companies to reduce the pain, and hypoglycemic incidences associated with injections in order to improve patient compliance While any new insulin delivery system requires health authorities' approval, to provide long term safety profile and insuring patients' acceptance The inhalation delivery system Exubera® has already become clinically available in the United States and Europe for patients with diabetes as non-invasive delivery systemread more
Citations
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Strategies for effective oral insulin delivery with modified chitosan nanoparticles: A review
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Quercetin in anti-diabetic research and strategies for improved quercetin bioavailability using polymer-based carriers – a review
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Evolution of Insulin Delivery Devices: From Syringes, Pens, and Pumps to DIY Artificial Pancreas.
TL;DR: The evolution of syringes, disposable, durable pens and connected pens, needles, tethered and patch insulin pumps, bionic pancreas, alternate controller-enabled infusion (ACE) pumps, and do-it-yourself artificial Pancreas systems (DIY-APS) are discussed.
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Cross-linked chitosan microspheres for oral delivery of insulin: Taguchi design and in vivo testing
S. Jose,Joana F. Fangueiro,J. Smitha,T.A. Cinu,A.J. Chacko,K. Premaletha,Eliana B. Souto,Eliana B. Souto +7 more
TL;DR: In vivo studies revealed a significant reduction in blood glucose level after administration of the optimized formulation, in comparison to a subcutaneous insulin injection, and chitosan microspheres were superior in terms of sustaining protein release over conventional insulin therapy.
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Design, characterisation, and bioefficiency of insulin-chitosan nanoparticles after stabilisation by freeze-drying or cross-linking.
M.B. Diop,N. Auberval,A. Viciglio,A. Langlois,William Bietiger,Carole Mura,C. Peronet,Akkiz Bekel,D. Julien David,Minjie Zhao,Michel Pinget,Nathalie Jeandidier,Christine Vauthier,Eric Marchioni,Yves Frere,Séverine Sigrist +15 more
TL;DR: It is shown that the combination of freeze drying and cross linking treatment is necessary to stabilize (freeze-drying) and increase bioefficiency (cross-linking) of self assembled NP in the delivery of insulin in vitro and in vivo.
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