Journal ArticleDOI
Recent developments in PDMS surface modification for microfluidic devices
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TLDR
This review will present recent research on surface modifications of PDMS using techniques ranging from metal layer coatings and layer‐by‐layer depositions to dynamic surfactant treatments and the adsorption of amphipathic proteins.Abstract:
PDMS is enjoying continued and ever increasing popularity as the material of choice for microfluidic devices due to its low cost, ease of fabrication, oxygen permeability and optical transparency. However, PDMS's hydrophobicity and fast hydrophobic recovery after surface hydrophilization, attributed to its low glass transition temperature of less than -120 degrees C, negatively impacts on the performance of PDMS-based microfluidic device components. This issue has spawned a flurry of research to devise longer lasting surface modifications of PDMS, with particular emphasis on microfluidic applications. This review will present recent research on surface modifications of PDMS using techniques ranging from metal layer coatings and layer-by-layer depositions to dynamic surfactant treatments and the adsorption of amphipathic proteins. We will also discuss significant advances that have been made with a broad palette of gas-phase processing methods including plasma processing, sol-gel coatings and chemical vapor deposition. Finally, we will present examples of applications and future prospects of modified PDMS surfaces in microfluidics, in areas such as molecular separations, cell culture in microchannels and biomolecular detection via immunoassays.read more
Citations
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Development of a Microfluidic Platform for Trace Lipid Analysis
Andrew Davic,Michael Cascio +1 more
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FRET Imaging in Three-dimensional Hydrogels.
TL;DR: An analysis method for ratiometric FRET probes that yields linear ratios over the probe activation range is described and it is shown that this method is compatible with other forms of FRET imaging, such as anisotropy measurement and fluorescence lifetime imaging (FLIM).
References
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Journal ArticleDOI
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Journal ArticleDOI
Characterization of polydimethylsiloxane (PDMS) properties for biomedical micro/nanosystems.
TL;DR: PDMS surface hydrophilicity and micro-textures were generally unaffected when exposed to the different chemicals, except for micro-texture changes after immersion in potassium hydroxide and buffered hydrofluoric, nitric, sulfuric, and hydrofluic acids.
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