Journal ArticleDOI
Recent developments in PDMS surface modification for microfluidic devices
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TLDR
This review will present recent research on surface modifications of PDMS using techniques ranging from metal layer coatings and layer‐by‐layer depositions to dynamic surfactant treatments and the adsorption of amphipathic proteins.Abstract:
PDMS is enjoying continued and ever increasing popularity as the material of choice for microfluidic devices due to its low cost, ease of fabrication, oxygen permeability and optical transparency. However, PDMS's hydrophobicity and fast hydrophobic recovery after surface hydrophilization, attributed to its low glass transition temperature of less than -120 degrees C, negatively impacts on the performance of PDMS-based microfluidic device components. This issue has spawned a flurry of research to devise longer lasting surface modifications of PDMS, with particular emphasis on microfluidic applications. This review will present recent research on surface modifications of PDMS using techniques ranging from metal layer coatings and layer-by-layer depositions to dynamic surfactant treatments and the adsorption of amphipathic proteins. We will also discuss significant advances that have been made with a broad palette of gas-phase processing methods including plasma processing, sol-gel coatings and chemical vapor deposition. Finally, we will present examples of applications and future prospects of modified PDMS surfaces in microfluidics, in areas such as molecular separations, cell culture in microchannels and biomolecular detection via immunoassays.read more
Citations
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Journal ArticleDOI
Highly uniform SERS-active microchannel on hydrophobic PDMS: a balance of high reproducibility and sensitivity for detection of proteins
TL;DR: SERS-active microchannels on hydrophobic polydimethylsiloxane (PDMS) with both high reproducibility and sensitivity are fabricated in this article, where uniform and size controllable silver nanoparticles (Ag NPs) are prepared with a two-step method, in which the nucleation and growth stages are carried out independently.
Journal ArticleDOI
A durable and biocompatible ascorbic acid-based covalent coating method of polydimethylsiloxane for dynamic cell culture
Joni Leivo,Sanni Virjula,Sari Vanhatupa,Kimmo Kartasalo,Joose Kreutzer,Susanna Miettinen,Pasi Kallio +6 more
TL;DR: A novel and simple method for binding collagen type I covalently on PDMS using ascorbic acid (AA) as a cross-linker instead of GA to provide a new PDMS coating method for studying cells, such as hASCs, in static and dynamic conditions.
Journal ArticleDOI
Enzyme Sensor With Polydimethylsiloxane Membrane and CMOS Potentiostat for Wide-Range Glucose Measurements
TL;DR: An electrochemical measurement setup comprising a glucose sensor and a CMOS potentiostat with a two-layer membrane as the first steps toward the development of an integrated in-situ sensor system for bioreactors are reported.
Journal ArticleDOI
Increased adhesion of polydimethylsiloxane (PDMS) to acrylic adhesive tape for medical use by surface treatment with an atmospheric pressure rotating plasma jet
José Antonio Jofre-Reche,Jerome Pulpytel,Jerome Pulpytel,Farzaneh Arefi-Khonsari,Farzaneh Arefi-Khonsari,José Miguel Martín-Martínez +5 more
TL;DR: In this article, the surface properties of polydimethylsiloxane (PDMS) were modified by treatment with an atmospheric pressure rotating plasma jet (APPJ) and the surface modifications were evaluated to assess its hydrophilicity and adhesion to acrylic adhesive tape intended for medical applications.
Journal ArticleDOI
Increasing silicone mold longevity: a review of surface modification techniques for PDMS-PDMS double casting.
TL;DR: In this paper, a soft lithography-based PDMS was used for microfluidic devices due to its chemical properties allowing for rapid molding and versatility in biological applications.
References
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TL;DR: The results of typical analyses obtained in the laboratories of the authors occupy eleven pages, and will prove, useful to analysts and others for reference and guidance; the list of important works of reference provided will also be equally serviceable.
Journal ArticleDOI
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Journal ArticleDOI
Characterization of polydimethylsiloxane (PDMS) properties for biomedical micro/nanosystems.
TL;DR: PDMS surface hydrophilicity and micro-textures were generally unaffected when exposed to the different chemicals, except for micro-texture changes after immersion in potassium hydroxide and buffered hydrofluoric, nitric, sulfuric, and hydrofluic acids.
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Journal ArticleDOI
Integrated microfluidic devices
David Erickson,Dongqing Li +1 more
TL;DR: In this paper, the authors provide an in-depth look at the state-of-the-art in integrated microfludic devices for a broad range of application areas from on-chip DNA analysis, immunoassays and cytometry to advances in integrated detection technologies for and miniaturized fuel processing devices.