Journal ArticleDOI
Recent developments in PDMS surface modification for microfluidic devices
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TLDR
This review will present recent research on surface modifications of PDMS using techniques ranging from metal layer coatings and layer‐by‐layer depositions to dynamic surfactant treatments and the adsorption of amphipathic proteins.Abstract:
PDMS is enjoying continued and ever increasing popularity as the material of choice for microfluidic devices due to its low cost, ease of fabrication, oxygen permeability and optical transparency. However, PDMS's hydrophobicity and fast hydrophobic recovery after surface hydrophilization, attributed to its low glass transition temperature of less than -120 degrees C, negatively impacts on the performance of PDMS-based microfluidic device components. This issue has spawned a flurry of research to devise longer lasting surface modifications of PDMS, with particular emphasis on microfluidic applications. This review will present recent research on surface modifications of PDMS using techniques ranging from metal layer coatings and layer-by-layer depositions to dynamic surfactant treatments and the adsorption of amphipathic proteins. We will also discuss significant advances that have been made with a broad palette of gas-phase processing methods including plasma processing, sol-gel coatings and chemical vapor deposition. Finally, we will present examples of applications and future prospects of modified PDMS surfaces in microfluidics, in areas such as molecular separations, cell culture in microchannels and biomolecular detection via immunoassays.read more
Citations
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Journal ArticleDOI
Adsorption Behavior of Hydrophobin Proteins on Polydimethylsiloxane Substrates
TL;DR: Atomistic molecular dynamics simulations have been conducted to elucidate the adsorption mechanism of HFBI on the PDMS substrate in an aqueous environment, and a set of residues consisting of Leu12, Leu24, Leo26, Ile27, Ala66, and Leu68 were found to play an important role in the Adsorption of H FBI on different hydrophobic substrates, irrespective of the structural features of the substrates.
Journal ArticleDOI
Synthesis of thiolated glycosaminoglycans and grafting to solid surfaces.
Alexander Köwitsch,Mauricio Jurado Abreu,Ankur Chhalotre,Martin Hielscher,Steffen Fischer,Karsten Mäder,Thomas Groth +6 more
TL;DR: The results of water contact angle measurement (WCA), ellipsometry and confocal laser scanning microscopy (CLSM) demonstrated that the resulting surface coverage was dependent on the degree of thiolation of GAGs.
Journal ArticleDOI
Biosynthetic, biomimetic, and self-assembled vascularized Organ-on-a-Chip systems
Anna Fritschen,Andreas Blaeser +1 more
TL;DR: A comprehensive technological review with a strong focus on the challenge of producing physiologically relevant vascular structures is given and the remaining obstacles and opportunities in the development of vascularized Organ-on-a-Chip platforms for advancing drug development and predictive disease modelling are noted.
Journal ArticleDOI
Silane surface modification for improved bioadhesion of esophageal stents
TL;DR: The results suggest that surface modification of esophageal SEMS via covalent attachment of protein-binding coupling agents improves adhesion to tissue and could offer a solution to reduce SEMS migration while preserving their removability.
Book ChapterDOI
Layer-by-Layer Assembly of Multifunctional Hybrid Materials and Nanoscale Devices
E. Seyrek,G. Decher +1 more
TL;DR: Layer-by-layer (LbL) assembly of nanoscale films has become a widely accepted method in academic and industrial research approaching an impact similar to that of a name reaction in organic chemistry.
References
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Journal ArticleDOI
Solvent compatibility of poly(dimethylsiloxane)-based microfluidic devices.
TL;DR: This paper describes the compatibility of poly(dimethylsiloxane) (PDMS) with organic solvents; this compatibility is important in considering the potential of PDMS-based microfluidic devices in a number of applications, including that of microreactors for organic reactions.
Journal ArticleDOI
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TL;DR: PDMS surface hydrophilicity and micro-textures were generally unaffected when exposed to the different chemicals, except for micro-texture changes after immersion in potassium hydroxide and buffered hydrofluoric, nitric, sulfuric, and hydrofluic acids.
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TL;DR: In this paper, the authors provide an in-depth look at the state-of-the-art in integrated microfludic devices for a broad range of application areas from on-chip DNA analysis, immunoassays and cytometry to advances in integrated detection technologies for and miniaturized fuel processing devices.