Journal ArticleDOI
Recent developments in PDMS surface modification for microfluidic devices
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TLDR
This review will present recent research on surface modifications of PDMS using techniques ranging from metal layer coatings and layer‐by‐layer depositions to dynamic surfactant treatments and the adsorption of amphipathic proteins.Abstract:
PDMS is enjoying continued and ever increasing popularity as the material of choice for microfluidic devices due to its low cost, ease of fabrication, oxygen permeability and optical transparency. However, PDMS's hydrophobicity and fast hydrophobic recovery after surface hydrophilization, attributed to its low glass transition temperature of less than -120 degrees C, negatively impacts on the performance of PDMS-based microfluidic device components. This issue has spawned a flurry of research to devise longer lasting surface modifications of PDMS, with particular emphasis on microfluidic applications. This review will present recent research on surface modifications of PDMS using techniques ranging from metal layer coatings and layer-by-layer depositions to dynamic surfactant treatments and the adsorption of amphipathic proteins. We will also discuss significant advances that have been made with a broad palette of gas-phase processing methods including plasma processing, sol-gel coatings and chemical vapor deposition. Finally, we will present examples of applications and future prospects of modified PDMS surfaces in microfluidics, in areas such as molecular separations, cell culture in microchannels and biomolecular detection via immunoassays.read more
Citations
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Surface Functionalization of Polymeric Resin by Polymer Brushes and Challenges in Future
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Principles, Materials, and Fabrication Methods of Microfluidics
TL;DR: In this article, the authors summarized the principles of fluid flow and highlighted the characteristics of the materials which are being used for the fabrication of microfluidic devices and presented the fabrication methods of micro-fluidics with recent developments.
Journal ArticleDOI
Research on the PDMS Surface Modification Technique
TL;DR: In this paper, the authors presented the experiment results of PDMS surface modification with three main modification techniques: UV radiation, oxygen plasma treatment and dynamical coating technique, which made the contact angle lowed to the 21° and exhibited the better hydrophilic character.
References
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Journal ArticleDOI
Solvent compatibility of poly(dimethylsiloxane)-based microfluidic devices.
TL;DR: This paper describes the compatibility of poly(dimethylsiloxane) (PDMS) with organic solvents; this compatibility is important in considering the potential of PDMS-based microfluidic devices in a number of applications, including that of microreactors for organic reactions.
Journal ArticleDOI
Characterization of polydimethylsiloxane (PDMS) properties for biomedical micro/nanosystems.
TL;DR: PDMS surface hydrophilicity and micro-textures were generally unaffected when exposed to the different chemicals, except for micro-texture changes after immersion in potassium hydroxide and buffered hydrofluoric, nitric, sulfuric, and hydrofluic acids.
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TL;DR: This work presents a meta-analysis of Capillary Electrophoresis for the Analysis of Single Cells: Electrochemical, Mass Spectrometric, and Radiochemical Detection, and its applications for Drugs in Biological Fluids.
Journal ArticleDOI
Integrated microfluidic devices
David Erickson,Dongqing Li +1 more
TL;DR: In this paper, the authors provide an in-depth look at the state-of-the-art in integrated microfludic devices for a broad range of application areas from on-chip DNA analysis, immunoassays and cytometry to advances in integrated detection technologies for and miniaturized fuel processing devices.