Journal ArticleDOI
Cellular and Molecular Regulation of Muscle Regeneration
TLDR
Recent evidence supports the possible contribution of adult stem cells in the muscle regeneration process and in particular, bone marrow-derived and muscle-derived stem cells contribute to new myofiber formation and to the satellite cell pool after injury.Abstract:
Charge, Sophie B. P., and Michael A. Rudnicki. Cellular and Molecular Regulation of Muscle Regeneration. Physiol Rev 84: 209–238, 2004; 10.1152/physrev.00019.2003.—Under normal circumstances, mamma...read more
Citations
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Mesenchymal stem cells reside in virtually all post-natal organs and tissues
TL;DR: The results suggest that the distribution of MSCs throughout the post-natal organism is related to their existence in a perivascular niche, which has implications for understanding MSC biology, and for clinical and pharmacological purposes.
Journal ArticleDOI
A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA
Marcella Cesana,Davide Cacchiarelli,Ivano Legnini,Tiziana Santini,Olga Sthandier,Mauro Chinappi,Anna Tramontano,Anna Tramontano,Irene Bozzoni +8 more
TL;DR: It is demonstrated that linc-MD1 exerts the same control over differentiation timing in human myoblasts, and that its levels are strongly reduced in Duchenne muscle cells, indicating that the ceRNA network plays an important role in muscle differentiation.
Journal ArticleDOI
Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
Aaron W. Joe,Lin Yi,Anuradha Natarajan,Fabien Le Grand,Leslie So,Joy X. Wang,Michael A. Rudnicki,Fabio M.V. Rossi +7 more
TL;DR: A new subpopulation of fibro/adipogenic progenitors (FAPs) resident in muscle tissue but arising from a distinct developmental lineage is described, which expand upon damage to provide a transient source of pro-differentiation signals for proliferating myogenic progensitors.
Journal ArticleDOI
Concise review: adipose tissue-derived stromal cells--basic and clinical implications for novel cell-based therapies.
TL;DR: Compared with bone marrow‐derived mesenchymal stem cells, adipose tissue‐derived stromal cells (ADSC) do have an equal potential to differentiate into cells and tissues of mesodermal origin, such as adipocytes, cartilage, bone, and skeletal muscle, but the easy and repeatable access to subcutaneous adipOSE tissue and the simple isolation procedures provide a clear advantage.
Journal ArticleDOI
Direct isolation of satellite cells for skeletal muscle regeneration.
Didier Montarras,Jennifer E. Morgan,Charlotte A. Collins,Frédéric Relaix,Stéphane Zaffran,Ana Cumano,Terence A. Partridge,Margaret Buckingham +7 more
TL;DR: A Pax3GFP/+ mouse line is used to directly isolate (Pax3)(green fluorescent protein)–expressing muscle satellite cells, by flow cytometry from adult skeletal muscles, as a homogeneous population of small, nongranular, Pax7+, CD34+, CD45–, Sca1– cells.
References
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Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member.
TL;DR: Results suggest that GDF-8 functions specifically as a negative regulator of skeletal muscle growth, which is significantly larger than wild-type animals and show a large and widespread increase in skeletal muscle mass.
Journal ArticleDOI
Satellite cell of skeletal muscle fibers.
TL;DR: In the course of an electron microscopic study of the peripheral region of the skeletal muscle fiber of the frog, the presence of certain cells, intimately associated with the muscle fiber, have been observed which the authors have chosen to call satellite cells.
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Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.
TL;DR: It is discovered that display of Hoechst fluorescence simultaneously at two emission wavelengths revealed a small and distinct subset of whole bone marrow cells that had phenotypic markers of multipotential HSC, which were shown in competitive repopulation experiments to contain the vast majority of HSC activity from murine bone marrow and to be enriched at least 1,000-fold for in vivo reconstitution activity.
Journal ArticleDOI
Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors
Giuliana Ferrari,Gabriella Cusella,Gabriella Cusella,D. De Angelis,D. De Angelis,M. Coletta,M. Coletta,Egle Paolucci,Egle Paolucci,Anna Stornaiuolo,Anna Stornaiuolo,Giulio Cossu,Giulio Cossu,Fulvio Mavilio,Fulvio Mavilio +14 more
TL;DR: Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers.
Journal ArticleDOI
Molecular cloning and expression of human hepatocyte growth factor
Toshikazu Nakamura,Tsutomu Nishizawa,Mitchio Hagiya,Tatsuya Seki,Manabu Shimonishi,Atsushi Sugimura,Kosuke Tashiro,Shin Shimizu +7 more
TL;DR: The nucleotide sequence of the human HGF cDNA reveals that both α- andβ-chains are contained in a single open reading frame coding for a pre-pro precursor protein of 728 amino acids, which indicates that the activity of HGF is not species-specific.