Journal ArticleDOI
Redistribution and Pinocytosis of Lymphocyte Surface Immunoglobulin Molecules Induced by Anti-Immunoglobulin Antibody
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TLDR
A possible mechanism for lymphocyte triggering by antigen is suggested and questions about cell membrane structure are raised.Abstract:
Antibody reacting with lymphocyte surface immunoglobulin molecules induces these to gather over one pole of the cell. This suggests a possible mechanism for lymphocyte triggering by antigen and raises questions about cell membrane structure.read more
Citations
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Journal ArticleDOI
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
TL;DR: 21-nucleotide siRNA duplexes provide a new tool for studying gene function in mammalian cells and may eventually be used as gene-specific therapeutics.
Journal ArticleDOI
The fluid mosaic model of the structure of cell membranes.
S. J. Singer,Garth L. Nicolson +1 more
TL;DR: Results strongly indicate that the bivalent antibodies produce an aggregation of the surface immunoglobulin molecules in the plane of the membrane, which can occur only if the immunoglOBulin molecules are free to diffuse in the membrane.
Book ChapterDOI
THE FLUID MOSAIC MODEL OF THE STRUCTURE OF CELL MEMBRANES Reprinted with permission from Science, Copyright AAA, 18 February 1972, Volume 175, pp. 720–731.
S. J. Singer,Garth L. Nicolson +1 more
TL;DR: Results strongly indicate that the bivalent antibodies produce an aggregation of the surface immunoglobulin molecules in the plane of the membrane, which can occur only if the immunoglOBulin molecules are free to diffuse in the membrane.
Journal ArticleDOI
Commentary. Lysosomotropic agents.
Journal ArticleDOI
Endocytosis and the recycling of plasma membrane.
TL;DR: This article centers on the properties and dynamics of the endocytic vacuole membrane and stresses observations on cultured mouse macrophages with which the authors are most familier.
References
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Journal ArticleDOI
The hydrolysis of rabbit γ-globulin and antibodies with crystalline papain
Journal ArticleDOI
Immunization of dissociated spleen cell cultures from normal mice
TL;DR: There is an increase in the ability to discriminate between different varieties of homologous erythrocytes and the in vitro response does not appear to be limited by whatever mechanisms regulate the in vivo response.
Journal ArticleDOI
Microfilaments in Cellular and Developmental Processes
Norman K. Wessells,Brian S. Spooner,J. F. Ash,M. O. Bradley,Marilyn A. Ludueña,E. L. Taylor,Joan T. Wrenn,Kenneth M. Yamada +7 more
TL;DR: The overall conclusion is that a broad spectrum of cellular and developmental processes are caused by contractile apparatuses that have at least the common feature of being sensitive to cytochalasin.
Journal ArticleDOI
The akr thymic antigen and its distribution in leukemias and nervous tissues
Arnold E. Reif,Joan M. Allen +1 more
TL;DR: A clear-cut serological differentiation between AKR lymphocytes of thymic and non-thymic origin is reported: these two cell types are antigenically distinct.
Journal ArticleDOI
The rapid intermixing of cell surface antigens after formation of mouse-human heterokaryons.
L. D. Frye,Michael Edidin +1 more
TL;DR: It appears that the cell surface of heterokaryons is not a rigid structure, but is ‘fluid’ enough to allow free ‘diffusion’ of surface antigens resulting in their intermingling within minutes after the initiation of fusion.