Journal ArticleDOI
Regional wall mechanics in the ischemic left ventricle: numerical modeling and dog experiments
Peter H. M. Bovendeerd,Theo Arts,Tammo Delhaas,Jacques M. Huyghe,D.H. van Campen,R. S. Reneman +5 more
TLDR
The mechanics of the ischemic left ventricle during a complete cardiac cycle were simulated using a finite-element model accounting for the thick-walled ventricular geometry, the fibrous nature of the myocardial tissue, and the dependency of active muscle fiber stress on time, strain, and strain rate.Abstract:
The mechanics of the ischemic left ventricle during a complete cardiac cycle were simulated using a finite-element model accounting for the thick-walled ventricular geometry, the fibrous nature of the myocardial tissue, and the dependency of active muscle fiber stress on time, strain, and strain rate. Ischemia was modeled by disabling the generation of active stress in a region comprising approximately 12% of total wall volume. In the model simulations, the approximately 12% reduction in the amount of normally contracting tissue resulted in an approximately 25% reduction in stroke work compared with the normal situation. The more-than-proportional loss of stroke work may partly be attributed to storage of elastic energy in the bulging ischemic region. Furthermore the mechanical performance in the nonischemic border zone deteriorated because of reduced systolic fiber stress (if fibers were in series with those in the ischemic region) or reduced fiber shortening (if fibers were parallel). The deformation pattern of the ventricle was asymmetric with respect to the ischemic region because of the anisotropy of the myocardial tissue. Epicardial fiber shortening in and around the ischemic region, as predicted from the model simulations, was in qualitative agreement with shortening, as measured in four dogs in which ischemia was induced by occlusion of the distal part of the left anterior interventricular coronary artery.read more
Citations
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Book ChapterDOI
Determination of Myocardial Material Properties by Optimization
TL;DR: This chapter is concerned with brief descriptions of the studies from the laboratory that have led up to current knowledge concerning regional variations of myocardial contractility in infarcted left ventricles.
Proceedings ArticleDOI
The simulation study of the influence of electrical asynchrony on regional mechanics of the ischemic ventricle using electromechanical heart models
TL;DR: In this paper, the influence of electrical asynchrony on regional mechanics of the ventricle is simulated based on electromechanical heart models, where deformation, strain and stress are calculated during systole phase.
Cardiac myofiber reorientation : a mechanism for adaptation?
TL;DR: The final author version and the galley proof are versions of the publication after peer review and the final published version features the final layout of the paper including the volume, issue and page numbers.
Book ChapterDOI
Adaptive Reorientation of Myofiber Orientation in a Model of Biventricular Cardiac Mechanics: The Effect of Triaxial Active Stress, Passive Shear Stiffness, and Activation Sequence
TL;DR: In this article, a model of adaptive reorientation of myofiber orientation was proposed as method for estimating myofibiber orientation, which resulted in an endo-to-epicardial component of fiber orientation, an improved pump function, and more realistic shear strain patterns.
Book ChapterDOI
In Vivo Myocardial Material Properties and Stress Distributions in Normal and Failing Human Hearts
Jonathan F. Wenk,Zhihong Zhang,Guangming Cheng,Kay Sun,Joseph C. Walker,David A. SalonerSaloner,Mark B. Ratcliffe,Julius M. Guccione +7 more
TL;DR: A noninvasive method for estimating myocardial material properties in vivo would be of great value in the design and evaluation of new surgical and medical strategies to treat and/or prevent heart failure.