Journal ArticleDOI
Regulation of enzymes of the urea cycle and arginine metabolism
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TLDR
This review emphasizes recent information regarding roles and regulation of urea cycle and arginine metabolic enzymes in liver and other cell types.About:
This article is published in Nutrition.The article was published on 2003-11-28. It has received 611 citations till now. The article focuses on the topics: Urea cycle & Arginase.read more
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Journal ArticleDOI
Isolation of amniotic stem cell lines with potential for therapy.
Paolo De Coppi,Georg Bartsch,M. Minhaj Siddiqui,Tao Xu,Cesar C. Santos,Laura Perin,Gustavo Mostoslavsky,Ang line C. Serre,Evan Y. Snyder,James J. Yoo,Mark E. Furth,Shay Soker,Anthony Atala +12 more
TL;DR: The isolation of human and rodent amniotic fluid–derived stem (AFS) cells that express embryonic and adult stem cell markers are reported and examples of differentiated cells derived from human AFS cells and displaying specialized functions include neuronal lineage cells secreting the neurotransmitter L-glutamate or expressing G-protein-gated inwardly rectifying potassium channels.
Journal ArticleDOI
Regulation of immune responses by L-arginine metabolism.
Vincenzo Bronte,Paola Zanovello +1 more
TL;DR: This Review article focuses on the relevance of L-arginine metabolism by myeloid cells for immunity under physiological and pathological conditions.
Journal ArticleDOI
Altered macrophage differentiation and immune dysfunction in tumor development
Antonio Sica,Vincenzo Bronte +1 more
TL;DR: A complete understanding of the complex interplay between neoplastic and myelomonocytic cells might offer novel targets for therapeutic intervention aimed at depriving tumor cells of important growth support and enhancing the antitumor immune response.
Journal ArticleDOI
Macrophage polarization in tumour progression.
Antonio Sica,Paola Larghi,Alessandra Mancino,Luca Rubino,Chiara Porta,Maria Grazia Totaro,Monica Rimoldi,Subhra K. Biswas,Paola Allavena,Alberto Mantovani,Alberto Mantovani +10 more
TL;DR: Recent findings suggesting that targeting tumour-associated macrophages (TAMs) polarization may represent a novel therapeutic strategy against cancer are discussed.
Journal ArticleDOI
Polyamines and cancer: old molecules, new understanding
TL;DR: Inhibition of polyamine synthesis has proven to be generally ineffective as an anticancer strategy in clinical trials, but it is a potent cancer chemoprevention strategy in preclinical studies as mentioned in this paper.
References
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Journal ArticleDOI
Amino Acid Metabolism in Mammalian Cell Cultures
TL;DR: The present article "is a progress report rather than a review and in large part summarizes studies from a single laboratory" on the minimal essential medium for cultivation of mammalian cells in either monolayer or suspension.
Journal ArticleDOI
Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells
Heather P. Harding,Isabel Novoa,Yuhong Zhang,Huiqing Zeng,Ronald C. Wek,Matthieu Schapira,David Ron +6 more
TL;DR: Protein kinases that phosphorylate the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) are activated in stressed cells and negatively regulate protein synthesis, resulting in the induction of the downstream gene CHOP (GADD153).
Journal ArticleDOI
Untersuchungen uber die Harnstoffbildung im Tierkörper
Hans Adolf Krebs,Kurt Henseleit +1 more
TL;DR: In this paper, auffindung des weges is studied, auf dem im tierischen Organismus die Synthese des Harnstoffs aus Ammoniak and Kohlensaure verlauft.
Journal ArticleDOI
Arginine metabolism : nitric oxide and beyond
Guoyao Wu,Sidney M. Morris +1 more
TL;DR: Physiological roles and relationships between the pathways of arginine synthesis and catabolism in vivo are complex and difficult to analyse, owing to compartmentalized expression of various enzymes at both organ and subcellular levels.
Book
Nitric oxide : biology and pathobiology
TL;DR: This book is the first comprehensive text on nitric oxide to cover all aspects - basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications.