Journal ArticleDOI
Relationship between fatty acid binding proteins, acetyl-CoA formation and fatty acid synthesis in developing human placenta
TLDR
As gestation proceeds and more lipids are required by the developing placenta fatty acid binding protein content, activity of ATP citrate lyase and rate of fatty acid synthesis increase indicating a cause and efect relationship between the demand of lipids and supply of precursor fatty acids during human placental development.Abstract:
The relationship between fatty acid binding proteins, ATP citrate lyase activity and fatty acid synthesis in developing human placenta has been studied. Fatty acid binding proteins reverse the inhibitory efect of palmitoyl-CoA and oleate on ATP citrate lyase and fatty acid synthesis. In the absence of these inhibitors fatty acid binding proteins activate ATP citrate lyase and stimulate [ 1-14 C] acetate incorporation into placental fatty acids indicating binding of endogenous inhibitors by these proteins. Thus these proteins regulate the supply of acetyl-CoA as well as the synthesis of fatty acids from that substrates. As gestation proceeds and more lipids are required by the developing placenta fatty acid binding protein content, activity of ATP citrate lyase and rate of fatty acid synthesis increase indicating a cause and efect relationship between the demand of lipids and supply of precursor fatty acids during human placental development.read more
Citations
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Journal ArticleDOI
Placental metabolism and its regulation in health and diabetes
Gernot Desoye,Eleazar Shafrir +1 more
Journal ArticleDOI
Characterization of cardiac fatty-acid-binding protein from human placenta. Comparison with placenta hepatic types.
TL;DR: Cardiac FABP acted in a more efficient way as a donor, indicating a distinct role of these proteins in human placenta, which furnishes a multiorgan system for the developing fetus.
Posted ContentDOI
Effects of Full-cycle Exposure to Difenoconazole in Parental Zebrafish on the Liver-gut Axis of F0 and F1 Generations
Tao Zhu,Jiwen Wang,Dong Li +2 more
TL;DR: It was found that long-term exposure to low doses of DCZ inhibited the liver-gut axis in males and females, and the liver and gut axis in F0 males were disturbed even in F1 generation without DCZ exposure.
References
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Journal ArticleDOI
A novel acyl-CoA-binding protein from bovine liver. Effect on fatty acid synthesis.
TL;DR: Bovine liver was shown to contain a hitherto undescribed medium-chain acyl-CoA-binding protein that co-purifies with fatty-acid-binding proteins, but was, unlike these proteins, unable to bind fatty acids.
Book ChapterDOI
[27] ATP citrate lyase (citrate-cleavage enzyme)
TL;DR: The isotopic method is employed when the ATP citrate lyase activity in some tissue is low, because of its high sensitivity, and the spectrophotometric method is used in the subsequent steps of purification.
Journal ArticleDOI
Citrate-cleavage enzyme, 'malic' enzyme and certain dehydrogenases in embryonic and growing chicks.
TL;DR: The increases in the activities of hepatic citrate-cleavage enzyme and ;malic' enzyme occurred simultaneously with a marked increase in lipogenesis, suggesting a relationship of these enzymes to lipogenesis in chick liver.
Journal ArticleDOI
Inhibition of rat liver acetyl coenzyme A carboxylase by long chain acyl coenzyme A and fatty acid. Modulation by fatty acid-binding protein.
Journal ArticleDOI
Synthesis and Degradation of Malic Enzyme in Chick Liver
TL;DR: The results suggest that the increased synthesis of malic enzyme may have been initiated by an increased flux through the pathway for fatty acid synthesis, particularly when neonatal chicks were fed.
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