Journal ArticleDOI
REM sleep behaviour disorder in Parkinson’s disease is associated with specific motor features
TLDR
The presence of altered motor subtypes in PD with RBD suggests that patients with PD and RBD may have a different underlying pattern of neurodegeneration than PD patients without RBD.Abstract:
Background: Rapid eye movement (REM) sleep behaviour disorder (RBD) is commonly associated with Parkinson’s disease (PD), and recent studies have suggested that RBD in PD is associated with increased cognitive impairment, waking EEG slowing, autonomic impairment and lower quality of life on mental health components. However, it is unclear whether the association of RBD in PD has implications for motor manifestations of the disease. Methods: The study evaluated 36 patients with PD for the presence of RBD by polysomnography. Patients underwent an extensive evaluation on and off medication by a movement disorders specialist blinded to the polysomnography results. Measures of disease severity, quantitative motor indices, motor subtypes, complications of therapy and response to therapy were assessed and compared using regression analysis that adjusted for disease duration and age. Results: Patients with PD and RBD were less likely to be tremor predominant (14% vs 53%; p Conclusions: The presence of altered motor subtypes in PD with RBD suggests that patients with PD and RBD may have a different underlying pattern of neurodegeneration than PD patients without RBD.read more
Citations
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Journal ArticleDOI
REM sleep behavior disorder
TL;DR: Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia manifested by vivid, often frightening dreams associated with simple or complex motor behavior during REM sleep as discussed by the authors.
Journal ArticleDOI
Identifying prodromal Parkinson's disease: Pre-Motor disorders in Parkinson's disease
Ronald B. Postuma,Dag Aarsland,Paolo Barone,David J. Burn,Christopher Hawkes,Wolfgang H. Oertel,Tjalf Ziemssen +6 more
TL;DR: The evidence for the utility of olfaction, RBD, autonomic markers, visual changes, mood disorders, and cognitive loss as markers of prodromal PD and the potential sensitivity and specificity of these markers are summarized.
Journal ArticleDOI
New Clinical Subtypes of Parkinson Disease and Their Longitudinal Progression: A Prospective Cohort Comparison With Other Phenotypes
Seyed-Mohammad Fereshtehnejad,Silvia Rios Romenets,Julius B. M. Anang,Véronique Latreille,Jean-François Gagnon,Ronald B. Postuma +5 more
TL;DR: It is recommended to screen patients with Parkinson disease for mild cognitive impairment, orthostatic hypotension, and RBD even at baseline visits to identify a diffuse/malignant subgroup of patients with PD for whom the most rapid progression rate could be expected.
Journal ArticleDOI
The spectrum of nonmotor symptoms in early Parkinson disease
Tien K. Khoo,Alison J. Yarnall,Gordon W Duncan,Shirley Coleman,John T. O'Brien,David J. Brooks,Roger A. Barker,David J. Burn +7 more
TL;DR: NMS are common in early PD and reflect the multisystem nature of the disorder, and may be detrimental to patients' functional status and sense of well-being even in the earliest stages of PD.
Journal ArticleDOI
Predictors of dementia in Parkinson disease: a prospective cohort study.
Julius B. M. Anang,Jean-François Gagnon,Josie-Anne Bertrand,Silvia Rios Romenets,Véronique Latreille,Michel Panisset,Jacques Montplaisir,Ronald B. Postuma +7 more
TL;DR: Cardiovascular autonomic dysfunction, REM sleep behavior disorder, color discrimination ability, and gait dysfunction strongly predict development of dementia in Parkinson disease.
References
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Journal ArticleDOI
The Timed “Up & Go”: A Test of Basic Functional Mobility for Frail Elderly Persons
TL;DR: This study evaluated a modified, timed version of the “Get‐Up and Go” Test (Mathias et al, 1986) in 60 patients referred to a Geriatric Day Hospital and suggested that the timed “Up & Go’ test is a reliable and valid test for quantifying functional mobility that may also be useful in following clinical change over time.
Journal ArticleDOI
Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
TL;DR: The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported, and these observations call into question current concepts of Parkinson's Disease as a single distinct morbid entity.
Journal ArticleDOI
Staging of brain pathology related to sporadic Parkinson’s disease
TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.
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