Journal ArticleDOI
Repeated amphetamine administration induces a prolonged augmentation of phosphorylated cyclase response element-binding protein and Fos-related antigen immunoreactivity in rat striatum
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TLDR
It is demonstrated that repeated amphetamine administration results in a prolonged induction of phosphorylated cyclase response element-binding protein and Fos-related antigen immunoreactivity in the dorsal striatum, indicating that alterations in striatal gene expression associated with the development of behavioral sensitization may be mediated, in part, by these transcription factors.About:
This article is published in Neuroscience.The article was published on 1995-11-01. It has received 94 citations till now. The article focuses on the topics: Amphetamine & Striatum.read more
Citations
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Journal ArticleDOI
Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins
T. Herdegen,J.D. Leah +1 more
TL;DR: This article reviews findings up to the end of 1997 about the inducible transcription factors c-Jun, JunB, JunD, c-Fos, FosB, Fra,1, Fra-2, Krox-20 (Egr-2) and Krox -24 (NGFI-A, Egr-1, Zif268) as they pertain to gene expression in the mammalian nervous system and describes their expression and possible roles in glial cells.
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A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants
TL;DR: The present review examines the literature and critically evaluates the extent to which the neural consequences of repeated psychostimulant administration are associated with the expression of behavioral sensitization.
Journal ArticleDOI
Addiction and the brain: The neurobiology of compulsion and its persistence
TL;DR: Evidence is reviewed for the possibility that compulsion and its persistence are based on a pathological usurpation of molecular mechanisms that are normally involved in memory, which is often initiated by exposure to drug-related cues.
Journal ArticleDOI
The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants
TL;DR: A review of the large number of subsequent studies addressing the roles of NMDA, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and metabotropic glutamate receptors in the development and expression of behavioral sensitization concludes that EAA projections originating in prefrontal cortex may play a particularly important role in theDevelopment of sensitization.
Proteins boundatadjacent DNA elements act synergistically toregulate humanproenkephalin cAMP inducible transcription
TL;DR: Together, the two DNA elements, EN KCRE‐1 and ENKCRE‐2 and the protein factors with which they interact, play a critical role in the transduction and reception of signals transmitted from cell surface receptors to the proenkephalin nuclear transcription complex.
References
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Journal ArticleDOI
Multiple receptors for dopamine.
John W. Kebabian,Donald B. Calne +1 more
TL;DR: Pharmacological and biochemical criteria can be used to separate those dopamine receptors which are linked to the enzyme adenylyl cyclase and those which are not.
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Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis
Terry E. Robinson,Jill B. Becker +1 more
TL;DR: There is not convincing evidence for an increase in postsynaptic DA receptors or in DA synthesis in animals sensitized to AMPH, but there is strong evidence to support the notion that behavioral sensitization is due to enhanced mesotelencephalic DA release, especially upon re-exposure to the drug.
Journal ArticleDOI
Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity
Peter W. Kalivas,Jane Stewart +1 more
TL;DR: It is found that the dopamine neurons of sensitized animals have become increasingly sensitive to excitatory pharmacological and environmental stimuli or desensitized to inhibitory regulation, and changes in cellular activity or protein synthesis may result in a change in the presynaptic regulation of axon terminal dopamine release.
Journal ArticleDOI
CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases
TL;DR: The results suggest that CaM kinases may transduce electrical signals to the nucleus and that CREB functions to integrate Ca2+ and cAMP signals.
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Neuronal adaptation to amphetamine and dopamine: Molecular mechanisms of prodynorphin gene regulation in rat striatum
Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis
Terry E. Robinson,Jill B. Becker +1 more