Journal ArticleDOI
Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells.
Qi Mu,Masoud Najafi +1 more
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TLDR
In this paper, a review explains how resveratrol can modulate interactions within the tumor microenvironment (TME), which includes various types of immune cells such as CD4++T lymphocytes, cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, macrophages, and T regulatory cells (Tregs).About:
This article is published in International Immunopharmacology.The article was published on 2021-06-23. It has received 21 citations till now. The article focuses on the topics: Cancer stem cell & Tumor microenvironment.read more
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The interactions of paclitaxel with tumour microenvironment.
TL;DR: In this article , the effects of paclitaxel on the anti-tumour immunity, immunosuppressive cells, hypoxia, and also angiogenesis are discussed.
Journal ArticleDOI
Non-coding RNAs and macrophage interaction in tumor progression.
Maliheh Entezari,Mehrdokht Sadrkhanloo,Mohsen Rashidi,Sholeh Etehad Asnaf,Afshin Taheriazam,M. Hashemi,Milad Ashrafizadeh,Ali Zarrabi,Navid Rabiee,Kiavash Hushmandi,Sepideh Mirzaei,Gautam Sethi +11 more
TL;DR: In this paper , the role of non-coding RNAs (ncRNAs) and exosomal ncRNAs derived from tumor cells or macrophages can be considered as non-invasive biomarkers for tumor diagnosis.
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Resveratrol Contrasts LPA-Induced Ovarian Cancer Cell Migration and Platinum Resistance by Rescuing Hedgehog-Mediated Autophagy.
Alessandra Ferraresi,Andrea Esposito,Carlo Girone,Letizia Vallino,Amreen Salwa,Ian Ghezzi,Suyanee Thongchot,Suyanee Thongchot,Chiara Vidoni,Danny N. Dhanasekaran,Ciro Isidoro +10 more
TL;DR: In this article, the role of autophagy and resveratrol in ovarian cancer malignancy was investigated, and the ability of RV to counteract Lysophosphatidic acid (LPA) activity.
Journal ArticleDOI
Targeting of the tumor immune microenvironment by metformin.
Abstract: Stimulating antitumor immunity is an attractive idea for suppressing tumors. CD4 + and CD8 + T cells as well as natural killer cells (NK) are the primary antitumor immune cells in the tumor microenvironment (TME). In contrast to these cells, regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), cancer-associated fibroblasts (CAFs), and tumor-associated macrophages (TAMs) release several molecules to suppress antitumor immunity and stimulate cancer cell invasion and proliferation. Adjuvant treatment with certain nontoxic agents is interesting to boost antitumor immunity. Metformin, which is known as an antidiabetes drug, can modulate both antitumor and protumor immune cells within TME. It has the ability to induce the proliferation of CD8 + T lymphocytes and NK cells. On the other hand, metformin attenuates polarization toward TAMs, CAFs, and Tregs. Metformin also may stimulate the antitumor activity of immune system cells, while it interrupts the positive cross-talk and interactions between immunosuppressive cells and cancer cells. The purpose of this review is to explain the basic mechanisms for the interactions and communications between immunosuppressive, anti-tumoral, and cancer cells within TME. Next, we discuss the modulating effects of metformin on various cells and secretions in TME.
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Nobiletin as an inducer of programmed cell death in cancer: a review
TL;DR: Nobiletin (NOB) is a herbal-derived agent with fascinating anti-cancer properties that may induce cancer cell killing by modulating other mechanisms that are involved in programmed cell death mechanisms.
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Journal ArticleDOI
Resveratrol inhibits hypoxia-driven ROS-induced invasive and migratory ability of pancreatic cancer cells via suppression of the Hedgehog signaling pathway.
TL;DR: Evaluating whether resveratrol affects hypoxia-induced reactive oxygen species (ROS) production and the activation of the Hedgehog (Hh) signaling pathway as well as the invasion and migration of pancreatic cancer shows evidence that resver atrol may be a potential candidate for the chemoprevention of cancer.
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The Escape of Cancer from T Cell-Mediated Immune Surveillance: HLA Class I Loss and Tumor Tissue Architecture.
Federico Garrido,Francisco Perea,Mónica Bernal,Abel Sánchez-Palencia,Natalia Aptsiauri,Francisco Ruiz-Cabello +5 more
TL;DR: Recent findings indicating that tumor HLA-I loss also correlates with a reduced intra-tumor T cell infiltration and with a specific reorganization of tumor tissue are summarized.
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Immune system in cancer radiotherapy: Resistance mechanisms and therapy perspectives.
Keywan Mortezaee,Masoud Najafi +1 more
TL;DR: Cellular and molecular consequences in the TME following radiotherapy and promising immune targets to enhance anti-tumor immunity are explained.
Journal ArticleDOI
Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies.
Valerio Gelfo,Donatella Romaniello,Martina Mazzeschi,Michela Sgarzi,Giada Grilli,Alessandra Morselli,Beatrice Manzan,Karim Rihawi,Mattia Lauriola +8 more
TL;DR: Activation of anti-apoptotic signaling pathways and senescence are some of the mechanisms recently proposed, but the role of IL-1 in tumor cells refractory to standard therapies needs to be further investigated.
Journal ArticleDOI
The Roles of Regulatory B Cells in Cancer
TL;DR: The aim of this review is to summarize the characteristics of BRegs and the roles of Bregs in cancer.