Journal ArticleDOI
Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells.
Qi Mu,Masoud Najafi +1 more
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TLDR
In this paper, a review explains how resveratrol can modulate interactions within the tumor microenvironment (TME), which includes various types of immune cells such as CD4++T lymphocytes, cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, macrophages, and T regulatory cells (Tregs).About:
This article is published in International Immunopharmacology.The article was published on 2021-06-23. It has received 21 citations till now. The article focuses on the topics: Cancer stem cell & Tumor microenvironment.read more
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The interactions of paclitaxel with tumour microenvironment.
TL;DR: In this article , the effects of paclitaxel on the anti-tumour immunity, immunosuppressive cells, hypoxia, and also angiogenesis are discussed.
Journal ArticleDOI
Non-coding RNAs and macrophage interaction in tumor progression.
Maliheh Entezari,Mehrdokht Sadrkhanloo,Mohsen Rashidi,Sholeh Etehad Asnaf,Afshin Taheriazam,M. Hashemi,Milad Ashrafizadeh,Ali Zarrabi,Navid Rabiee,Kiavash Hushmandi,Sepideh Mirzaei,Gautam Sethi +11 more
TL;DR: In this paper , the role of non-coding RNAs (ncRNAs) and exosomal ncRNAs derived from tumor cells or macrophages can be considered as non-invasive biomarkers for tumor diagnosis.
Journal ArticleDOI
Resveratrol Contrasts LPA-Induced Ovarian Cancer Cell Migration and Platinum Resistance by Rescuing Hedgehog-Mediated Autophagy.
Alessandra Ferraresi,Andrea Esposito,Carlo Girone,Letizia Vallino,Amreen Salwa,Ian Ghezzi,Suyanee Thongchot,Suyanee Thongchot,Chiara Vidoni,Danny N. Dhanasekaran,Ciro Isidoro +10 more
TL;DR: In this article, the role of autophagy and resveratrol in ovarian cancer malignancy was investigated, and the ability of RV to counteract Lysophosphatidic acid (LPA) activity.
Journal ArticleDOI
Targeting of the tumor immune microenvironment by metformin.
Abstract: Stimulating antitumor immunity is an attractive idea for suppressing tumors. CD4 + and CD8 + T cells as well as natural killer cells (NK) are the primary antitumor immune cells in the tumor microenvironment (TME). In contrast to these cells, regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), cancer-associated fibroblasts (CAFs), and tumor-associated macrophages (TAMs) release several molecules to suppress antitumor immunity and stimulate cancer cell invasion and proliferation. Adjuvant treatment with certain nontoxic agents is interesting to boost antitumor immunity. Metformin, which is known as an antidiabetes drug, can modulate both antitumor and protumor immune cells within TME. It has the ability to induce the proliferation of CD8 + T lymphocytes and NK cells. On the other hand, metformin attenuates polarization toward TAMs, CAFs, and Tregs. Metformin also may stimulate the antitumor activity of immune system cells, while it interrupts the positive cross-talk and interactions between immunosuppressive cells and cancer cells. The purpose of this review is to explain the basic mechanisms for the interactions and communications between immunosuppressive, anti-tumoral, and cancer cells within TME. Next, we discuss the modulating effects of metformin on various cells and secretions in TME.
Journal ArticleDOI
Nobiletin as an inducer of programmed cell death in cancer: a review
TL;DR: Nobiletin (NOB) is a herbal-derived agent with fascinating anti-cancer properties that may induce cancer cell killing by modulating other mechanisms that are involved in programmed cell death mechanisms.
References
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Journal ArticleDOI
Resveratrol exerts antitumor effects by downregulating CD8+CD122+ Tregs in murine hepatocellular carcinoma.
Qunfang Zhang,Haiding Huang,Fang Zheng,Huazhen Liu,Feifei Qiu,Yuchao Chen,Chun-Ling Liang,Zhenhua Dai +7 more
TL;DR: A new immune mechanism underlying the immunosuppressive tumor microenvironment is unveiled and it is demonstrated that resveratrol could help reverse it by diminishing CD8+CD122+ Tregs.
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Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis
Habibie,Satoru Yokoyama,Sherif Abdelhamed,Suresh Awale,Hiroaki Sakurai,Yoshihiro Hayakawa,Ikuo Saiki +6 more
TL;DR: It is established that targeting survivin could provide an opportunity to treat melanoma patients through the down regulation of survivin transcription by resveratrol through the suppression of β-catenin and STAT3.
Journal ArticleDOI
Radiotherapy-induced overexpression of exosomal miRNA-378a-3p in cancer cells limits natural killer cells cytotoxicity.
Joséphine Briand,Delphine Garnier,Arulraj Nadaradjane,Karen Clément-Colmou,Vincent Potiron,Stéphane Supiot,Gwenola Bougras-Cartron,Jean-Sébastien Frenel,Dominique Heymann,François M. Vallette,Pierre-François Cartron +10 more
TL;DR: This work identifies TexomiR-378a-3p as a molecular signature associated with the loss of NK cells cytotoxicity via the decrease of GZMB expression upon radiotherapy.
Journal ArticleDOI
Specific immune recognition of pancreatic carcinoma by patient-derived CD4 and CD8 T cells and its improvement by interferon-γ
Friedrich H. Schmitz-Winnenthal,L. V. Galindo Escobedo,Philipp Beckhove,Volker Schirrmacher,Mariana Bucur,Yvonne Ziouta,Christine Volk,Bruno M. Schmied,M. Koch,Dalibor Antolovic,Jürgen Weitz,M.W. Büchler,Kaspar Z'graggen +12 more
TL;DR: Interferon-gamma appears to be a useful adjuvant cytokine to enhance the immunogenicity of a patients' tumor cells and their recognition by tumor reactive immune cells.
Journal ArticleDOI
Regulation of Apoptosis and Radiation Sensitization in Lung Cancer Cells via the Sirt1/NF-κB/Smac Pathway.
Kaihua Ji,Xiaohui Sun,Yang Liu,Liqing Du,Yan Wang,Ningning He,Jinhan Wang,Chang Xu,Qiang Liu +8 more
TL;DR: SirT1 regulates apoptosis and radiation sensitization in lung cancer cell lines A549 and H460 via the SirT1/NF-κB/Smac pathway, which could provide potential targets for cancer therapy.