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Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells.
Qi Mu,Masoud Najafi +1 more
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TLDR
In this paper, a review explains how resveratrol can modulate interactions within the tumor microenvironment (TME), which includes various types of immune cells such as CD4++T lymphocytes, cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, macrophages, and T regulatory cells (Tregs).About:
This article is published in International Immunopharmacology.The article was published on 2021-06-23. It has received 21 citations till now. The article focuses on the topics: Cancer stem cell & Tumor microenvironment.read more
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Journal ArticleDOI
The interactions of paclitaxel with tumour microenvironment.
TL;DR: In this article , the effects of paclitaxel on the anti-tumour immunity, immunosuppressive cells, hypoxia, and also angiogenesis are discussed.
Journal ArticleDOI
Non-coding RNAs and macrophage interaction in tumor progression.
Maliheh Entezari,Mehrdokht Sadrkhanloo,Mohsen Rashidi,Sholeh Etehad Asnaf,Afshin Taheriazam,M. Hashemi,Milad Ashrafizadeh,Ali Zarrabi,Navid Rabiee,Kiavash Hushmandi,Sepideh Mirzaei,Gautam Sethi +11 more
TL;DR: In this paper , the role of non-coding RNAs (ncRNAs) and exosomal ncRNAs derived from tumor cells or macrophages can be considered as non-invasive biomarkers for tumor diagnosis.
Journal ArticleDOI
Resveratrol Contrasts LPA-Induced Ovarian Cancer Cell Migration and Platinum Resistance by Rescuing Hedgehog-Mediated Autophagy.
Alessandra Ferraresi,Andrea Esposito,Carlo Girone,Letizia Vallino,Amreen Salwa,Ian Ghezzi,Suyanee Thongchot,Suyanee Thongchot,Chiara Vidoni,Danny N. Dhanasekaran,Ciro Isidoro +10 more
TL;DR: In this article, the role of autophagy and resveratrol in ovarian cancer malignancy was investigated, and the ability of RV to counteract Lysophosphatidic acid (LPA) activity.
Journal ArticleDOI
Targeting of the tumor immune microenvironment by metformin.
Abstract: Stimulating antitumor immunity is an attractive idea for suppressing tumors. CD4 + and CD8 + T cells as well as natural killer cells (NK) are the primary antitumor immune cells in the tumor microenvironment (TME). In contrast to these cells, regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), cancer-associated fibroblasts (CAFs), and tumor-associated macrophages (TAMs) release several molecules to suppress antitumor immunity and stimulate cancer cell invasion and proliferation. Adjuvant treatment with certain nontoxic agents is interesting to boost antitumor immunity. Metformin, which is known as an antidiabetes drug, can modulate both antitumor and protumor immune cells within TME. It has the ability to induce the proliferation of CD8 + T lymphocytes and NK cells. On the other hand, metformin attenuates polarization toward TAMs, CAFs, and Tregs. Metformin also may stimulate the antitumor activity of immune system cells, while it interrupts the positive cross-talk and interactions between immunosuppressive cells and cancer cells. The purpose of this review is to explain the basic mechanisms for the interactions and communications between immunosuppressive, anti-tumoral, and cancer cells within TME. Next, we discuss the modulating effects of metformin on various cells and secretions in TME.
Journal ArticleDOI
Nobiletin as an inducer of programmed cell death in cancer: a review
TL;DR: Nobiletin (NOB) is a herbal-derived agent with fascinating anti-cancer properties that may induce cancer cell killing by modulating other mechanisms that are involved in programmed cell death mechanisms.
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Journal ArticleDOI
Mitigation of Radiation-induced Pneumonitis and Lung Fibrosis using Alpha-lipoic Acid and Resveratrol.
Rasoul Azmoonfar,Peyman Amini,Rasoul Yahyapour,Abolhassan Rezaeyan,Alireza Tavassoli,Elahe Motevaseli,Ehsan Khodamoradi,Dheyauldeen Shabeeb,Ahmed Eleojo Musa,Masoud Najafi +9 more
TL;DR: Alpha-lipoic acid and its combination with resveratrol were able to mitigate fibrosis and pneumonitis markers in mice lung tissues following lung irradiation, suggesting that the combination of resver atrol and alpha-lipOic acid has a potent mitigatory effect compared to the single forms of these agents.
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Resveratrol Inhibited Non–small Cell Lung Cancer Through Inhibiting STAT-3 Signaling
TL;DR: The results suggest that the anticancer effects of resveratrol are mediated by STAT‐3 signaling, which has demonstrated many beneficial effects against cancers but the mechanism remains unclear.
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Resveratrol stimulates the metabolic reprogramming of human CD4+ T cells to enhance effector function
Marco Craveiro,Marco Craveiro,Gaspard Cretenet,Cédric Mongellaz,Maria I. Matias,Olivier Caron,Olivier Caron,Maria C. Pedroso de Lima,Valérie S. Zimmermann,Eric Solary,Eric Solary,Valerie Dardalhon,Vjekoslav Dulic,Naomi Taylor +13 more
TL;DR: It is found that at high concentrations of resveratrol, human CD4+ T cells showed defective antigen receptor signaling and arrest at the G1 stage of the cell cycle, whereas at low concentrations, cells were readily activated and exhibited enhanced Sirt1 deacetylase activity.
Journal ArticleDOI
Targeting the Redox Landscape in Cancer Therapy.
TL;DR: Extracellular vesicles, such as exosomes, are crucial for the development of the hypoxic tumor microenvironment, and hence are explored as target and as drug delivery systems in cancer therapy.
Journal ArticleDOI
Resveratrol Induces Apoptosis and Attenuates Proliferation of MCF-7 Cells in Combination with Radiation and Hyperthermia.
Peyman Amini,Saeedeh Jafari Nodooshan,Milad Ashrafizadeh,Seyed-Mohammad Eftekhari,Tayebeh Aryafar,Leila Khalafi,Ahmed Eleojo Musa,Seyed Rabie Mahdavi,Masoud Najafi,Bagher Farhood +9 more
TL;DR: Results of this study suggest that resveratrol is able to induce the regulation of pro-apoptotic genes and attenuate the viability of MCF-7 cells, which may indicate the sensitizing effect of resver atrol in combination with both radiotherapy and hyperthermia.