Role of Insulin Resistance in MAFLD
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TLDR
In this article, the authors provide an overview of the factors contributing to and the role of systemic and local insulin resistance in the development and progression of MAFLD with hepatic insulin resistance.Abstract:
Many studies have reported that metabolic dysfunction is closely involved in the complex mechanism underlying the development of non-alcoholic fatty liver disease (NAFLD), which has prompted a movement to consider renaming NAFLD as metabolic dysfunction-associated fatty liver disease (MAFLD). Metabolic dysfunction in this context encompasses obesity, type 2 diabetes mellitus, hypertension, dyslipidemia, and metabolic syndrome, with insulin resistance as the common underlying pathophysiology. Imbalance between energy intake and expenditure results in insulin resistance in various tissues and alteration of the gut microbiota, resulting in fat accumulation in the liver. The role of genetics has also been revealed in hepatic fat accumulation and fibrosis. In the process of fat accumulation in the liver, intracellular damage as well as hepatic insulin resistance further potentiates inflammation, fibrosis, and carcinogenesis. Increased lipogenic substrate supply from other tissues, hepatic zonation of Irs1, and other factors, including ER stress, play crucial roles in increased hepatic de novo lipogenesis in MAFLD with hepatic insulin resistance. Herein, we provide an overview of the factors contributing to and the role of systemic and local insulin resistance in the development and progression of MAFLD.read more
Citations
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Journal ArticleDOI
Metabolic dysfunction-associated fatty liver disease and implications for cardiovascular risk and disease prevention
Xiaohong Zhou,Jingjing Cai,Giovanni Targher,Christopher D. Byrne,Michael D. Shapiro,Ki Chul Sung,Virend K. Somers,C. Anwar A. Chahal,Jacob George,Li-Li Chen,Yong Zhou,Ming-Hua Zheng +11 more
TL;DR: In this paper , a new term "metabolic dysfunction-associated fatty liver disease" (MAFLD) was proposed to better reflect the pathophysiology and cardiometabolic implications of common liver disease.
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Prevalence and characteristics of MAFLD in Chinese adults aged 40 years or older: A community-based study.
TL;DR: Wang et al. as discussed by the authors investigated the similarities and differences in the prevalence and clinical characteristics of MAFLD and NAFLD in Chinese adults, and found that the prevalence of MA FLD (40.3%) was significantly higher than that of NFLD (36.9%) (P < 0.05).
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Insulin Resistance Is Cheerfully Hitched with Hypertension
Susmita Sinha,Mainul Haque +1 more
TL;DR: Hypertension and insulin resistance are strongly related to an increased risk of impaired glucose tolerance, diabetes, cardiovascular diseases (CVD), and endocrine disorders, which is aggravated by hypertension.
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Detangling the interrelations between MAFLD, insulin resistance, and key hormones
TL;DR: The basis of the most important hormonal factors involved in the development and progression of MAFLD are reviewed, which include nutrition and the gut microbiome, as well as genetic and epigenetic influences.
Journal ArticleDOI
Ferroptosis and metabolic dysfunction‐associated fatty liver disease: Is there a link?
TL;DR: The mechanisms of ferroptosis and its putative pathogenic role inMAFLD are discussed to highlight potential new research directions and ideas for the prevention and treatment of MAFLD.
References
More filters
Journal ArticleDOI
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
TL;DR: A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.
Journal ArticleDOI
Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes
Zobair M. Younossi,Zobair M. Younossi,Aaron B. Koenig,Dinan Abdelatif,Yousef Fazel,Linda Henry,Mark Wymer,Mark Wymer +7 more
TL;DR: As the global epidemic of obesity fuels metabolic conditions, the clinical and economic burden of NAFLD will become enormous, and random‐effects models were used to provide point estimates of prevalence, incidence, mortality and incidence rate ratios.
Journal ArticleDOI
Sarcopenia: Revised European consensus on definition and diagnosis
Alfonso J. Cruz-Jentoft,Gulistan Bahat,Jürgen M. Bauer,Yves Boirie,Olivier Bruyère,Tommy Cederholm,Cyrus Cooper,Francesco Landi,Yves Rolland,Avan Aihie Sayer,Stéphane M. Schneider,Cornel C. Sieber,Eva Topinkova,Maurits Vandewoude,Marjolein Visser,Mauro Zamboni +15 more
TL;DR: An emphasis is placed on low muscle strength as a key characteristic of sarcopenia, uses detection of low muscle quantity and quality to confirm the sarc Openia diagnosis, and provides clear cut-off points for measurements of variables that identify and characterise sarc openia.
Journal ArticleDOI
Metabolic endotoxemia initiates obesity and insulin resistance
Patrice D. Cani,Jacques Amar,Miguel A. Iglesias,Marjorie Poggi,Claude Knauf,Delphine Bastelica,Audrey M. Neyrinck,Francesca Fava,Kieran Tuohy,Chantal Chabo,Aurélie Waget,Evelyne Delmée,Béatrice Cousin,Thierry Sulpice,Bernard Chamontin,Jean Ferrières,Jean-François Tanti,Glenn R. Gibson,Louis Casteilla,Nathalie M. Delzenne,Marie-Christine Alessi,Rémy Burcelin +21 more
TL;DR: It is concluded that the LPS/CD14 system sets the tone of insulin sensitivity and the onset of diabetes and obesity and lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases.
Journal ArticleDOI
Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.
TL;DR: A novel estimate of insulin sensitivity that is simple to calculate and provides a reasonable approximation of whole-body insulin sensitivity from the oral glucose tolerance test (OGTT).