Journal ArticleDOI
Scales of solute hydrogen-bonding: their construction and application to physicochemical and biochemical processes
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This article is published in Chemical Society Reviews.The article was published on 1993-01-01. It has received 1896 citations till now. The article focuses on the topics: Solvation & High-performance liquid chromatography.read more
Citations
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Determination of Abraham model solute descriptors for benzoin based on measured solubility ratios
Timothy W. Stephens,Matthew Loera,Monica Calderas,Ricardo Diaz,Nicholas Montney,William E. Acree,Michael H. Abraham +6 more
TL;DR: In this article, the experimental solubilities of benzoin were reported for 1 chloroalkane, 15 alcohols, 5 aromatic hydrocarbons, 5 alkyl acetates, 5 alkoxyalcohols and 3 ethers.
Journal ArticleDOI
Effect of n-octanol in the mobile phase on lipophilicity determination by reversed-phase high-performance liquid chromatography on a modified silica column.
Deborah Benhaim,Eli Grushka +1 more
TL;DR: It is shown that the addition of n-octanol to the mobile phase improves the chromatographic determination of lipophilicity parameters of xenobiotics (neutral solutes, acidic, neutral and basic drugs) on a Phenomenex Gemini C18 column.
Journal ArticleDOI
Solvation parameter model of comprehensive two-dimensional gas chromatography separations.
TL;DR: It is concluded that the GC x GC solvation parameter model is sufficiently accurate to aid in the identification of optimal column combinations and to generate primary retention time predictions with standard errors that were approximately 5% of the range of the experimental values.
Journal ArticleDOI
Characterization of new R-naphthylethyl cyclofructan 6 chiral stationary phase and its comparison with R-naphthylethyl β-cyclodextrin-based column
TL;DR: The LFER results showed that hydrogen bond acidity and polarity/polarizibility have the greatest impact on retention and enantioresolution on the RN CF6 CSP.
Journal ArticleDOI
Changes in energy of three types of hydrogen bonds upon excitation of aminocoumarins determined from absorption solvatochromic experiments
TL;DR: The results obtained for the aminocoumarins in HFIP, which in contrast to aliphatic alcohols does not form hydrogen bonds of the acceptor type, prove that the decrease in the energy of the NH-O hydrogen bond upon excitation to the lowest S(1)-LE state is significantly greater than the increase in theEnergy of hydrogen bonds made by the oxygen atom of carbonyl group OH-O.
References
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Journal ArticleDOI
The use of characteristic volumes to measure cavity terms in reversed phase liquid chromatography
Michael H. Abraham,J. C. McGowan +1 more
TL;DR: In this paper, it was shown that the use of the McGowans characteristic volume, Vx, is equivalent to using Leahy's computer-calculated intrinsic volumes, V1, for the cavity term mV/100, for 209 gaseous, liquid, and solid solutes.
Journal ArticleDOI
Do general anaesthetics act by competitive binding to specific receptors
Nicholas P. Franks,W. R. Lieb +1 more
TL;DR: It is shown that, over a 100,000-fold range of potencies, the activity of a pure soluble protein can be inhibited by 50% at anaesthetic concentrations which are essentially identical to those which anaesthetize animals.
Journal ArticleDOI
Hydrogen bonding: XVI. A new solute salvation parameter, π2H, from gas chromatographic data
TL;DR: In this article, the general salvation equation, log VG0 (or log L) was used to set up a new π2H parameter of solute dipolarity-polarisability, mainly through the extensive data of McReynolds and Patte et al.
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Determination of sets of solute descriptors from chromatographic measurements
The use of characteristic volumes to measure cavity terms in reversed phase liquid chromatography
Michael H. Abraham,J. C. McGowan +1 more