Journal ArticleDOI
Scales of solute hydrogen-bonding: their construction and application to physicochemical and biochemical processes
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This article is published in Chemical Society Reviews.The article was published on 1993-01-01. It has received 1896 citations till now. The article focuses on the topics: Solvation & High-performance liquid chromatography.read more
Citations
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PAMPA--a drug absorption in vitro model 13. Chemical selectivity due to membrane hydrogen bonding: in combo comparisons of HDM-, DOPC-, and DS-PAMPA models.
Alex Avdeef,Oksana Tsinman +1 more
TL;DR: It was shown that PAMPA permeability values consistently rank in magnitude according to: DS>DOPC>HDM, with molecules like metoprolol showing 1000-fold greater permeability in DS than in HDM.
Journal ArticleDOI
Application of hydrogen bonding calculations in property based drug design.
Michael H. Abraham,Adam Ibrahim,Andreas M. Zissimos,Yuan H. Zhao,John Comer,Derek P. Reynolds +5 more
TL;DR: The solvation equations can be interpreted to provide a qualitative chemical insight into biological partition and transport mechanisms and applications to blood-brain partition and human intestinal absorption are discussed.
Journal ArticleDOI
Recent advances of ionic liquids in separation science and mass spectrometry
TL;DR: Ionic liquids have drawn considerable interest for their use in various analytical techniques including chromatography, extractions, and mass spectrometry as discussed by the authors, largely due to the flexibility in tuning the physicochemical properties of ILs.
Journal ArticleDOI
Column Characterization and Selection Systems in Reversed-Phase High-Performance Liquid Chromatography
Petar Žuvela,Magdalena Skoczylas,J. Jay Liu,Tomasz Bączek,Roman Kaliszan,Ming Wah Wong,Bogusław Buszewski,Károly Héberger +7 more
TL;DR: This review aims for this review to be a comprehensive, authoritative, critical, and easily readable monograph of the most relevant publications regarding column selection and characterization in RP-HPLC covering the past four decades.
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Determination of solute lipophilicity, as log P(octanol) and log P(alkane) using poly(styrene–divinylbenzene) and immobilised artificial membrane stationary phases in reversed-phase high-performance liquid chromatography
Michael H. Abraham,Harpreet S. Chadha,Ruben A.E Leitao,Robert C. Mitchell,William J. Lambert,Roman Kaliszan,Antoni Nasal,P. Haber +7 more
TL;DR: In this paper, the linear free energy relationship (LFE) was used to characterize RP-HPLC systems with poly(styrene-divinylbenzene) phases, as log Palk or log Pcyc, where the latter is the water cyclohexane partition coefficient.
References
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Journal ArticleDOI
The use of characteristic volumes to measure cavity terms in reversed phase liquid chromatography
Michael H. Abraham,J. C. McGowan +1 more
TL;DR: In this paper, it was shown that the use of the McGowans characteristic volume, Vx, is equivalent to using Leahy's computer-calculated intrinsic volumes, V1, for the cavity term mV/100, for 209 gaseous, liquid, and solid solutes.
Journal ArticleDOI
Do general anaesthetics act by competitive binding to specific receptors
Nicholas P. Franks,W. R. Lieb +1 more
TL;DR: It is shown that, over a 100,000-fold range of potencies, the activity of a pure soluble protein can be inhibited by 50% at anaesthetic concentrations which are essentially identical to those which anaesthetize animals.
Journal ArticleDOI
Hydrogen bonding: XVI. A new solute salvation parameter, π2H, from gas chromatographic data
TL;DR: In this article, the general salvation equation, log VG0 (or log L) was used to set up a new π2H parameter of solute dipolarity-polarisability, mainly through the extensive data of McReynolds and Patte et al.
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Determination of sets of solute descriptors from chromatographic measurements
The use of characteristic volumes to measure cavity terms in reversed phase liquid chromatography
Michael H. Abraham,J. C. McGowan +1 more