Journal ArticleDOI
Scales of solute hydrogen-bonding: their construction and application to physicochemical and biochemical processes
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This article is published in Chemical Society Reviews.The article was published on 1993-01-01. It has received 1896 citations till now. The article focuses on the topics: Solvation & High-performance liquid chromatography.read more
Citations
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Journal ArticleDOI
How hydrogen bonds impact P-glycoprotein transport and permeability
TL;DR: The benefits of considering the relative strengths of individual H-bonds and introducing intramolecular H- bonds to increase membrane permeability and/or decrease P-gp efflux are illustrated.
Journal ArticleDOI
Hydrogen bonding: XXXV. Relationship between high-performance liquid chromatography capacity factors and water-octanol partition coefficients
TL;DR: In this article, it was shown that the blend of factors that influence log k in any given system is not the same as that which influences log Poct, and that when log k' values are used to estimate log poct, great care has to be taken to match the training set of solutes in the correlation equation, with the solutes for which log PoCT is to be determined.
Journal ArticleDOI
Binding Features of Molecular Clips. Separation of the Effects of Hydrogen Bonding and π−π Interactions
Joost N. H. Reek,Alex H. Priem,Hans Engelkamp,Alan E. Rowan,Johannes A. A. W. Elemans,Roeland J. M. Nolte +5 more
TL;DR: In this paper, the ability of clip-shaped molecules based on the building block diphenylglycoluril to form complexes with dihydroxybenzene guest molecules has been studied in detail.
Journal ArticleDOI
Hydrogen bonding descriptors in the prediction of human in vivo intestinal permeability.
TL;DR: The combination of a hydrogen bond donor descriptor, a general hydrogen bonding descriptor and a lipophilicity descriptor enabled the prediction of human intestinal permeability, whereas hydrogen bond acceptor descriptors were found to be less important.
Journal ArticleDOI
Compilation and Correlation of Limiting Activity Coefficients of Nonelectrolytes in Water
Steven R. Sherman,Diane B. Trampe,Diane B. Trampe,David Bush,Martin Schiller,Martin Schiller,Charles A. Eckert,Andrew J. Dallas,Jianjun Li,Jianjun Li,Peter W. Carr +10 more
TL;DR: The phase equilibria of dilute aqueous solutions are treated separately from those of the dilute organic systems due to water's unique structure and hydrogen-bonding characteristics as mentioned in this paper.
References
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Journal ArticleDOI
The use of characteristic volumes to measure cavity terms in reversed phase liquid chromatography
Michael H. Abraham,J. C. McGowan +1 more
TL;DR: In this paper, it was shown that the use of the McGowans characteristic volume, Vx, is equivalent to using Leahy's computer-calculated intrinsic volumes, V1, for the cavity term mV/100, for 209 gaseous, liquid, and solid solutes.
Journal ArticleDOI
Do general anaesthetics act by competitive binding to specific receptors
Nicholas P. Franks,W. R. Lieb +1 more
TL;DR: It is shown that, over a 100,000-fold range of potencies, the activity of a pure soluble protein can be inhibited by 50% at anaesthetic concentrations which are essentially identical to those which anaesthetize animals.
Journal ArticleDOI
Hydrogen bonding: XVI. A new solute salvation parameter, π2H, from gas chromatographic data
TL;DR: In this article, the general salvation equation, log VG0 (or log L) was used to set up a new π2H parameter of solute dipolarity-polarisability, mainly through the extensive data of McReynolds and Patte et al.
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Determination of sets of solute descriptors from chromatographic measurements
The use of characteristic volumes to measure cavity terms in reversed phase liquid chromatography
Michael H. Abraham,J. C. McGowan +1 more