Journal ArticleDOI
Selenium Biofortification of Agricultural Crops and Effects on Plant Nutrients and Bioactive Compounds Important for Human Health and Disease Prevention - a Review.
TLDR
The effects of selenium biofortification on selenum content, other minerals, and antioxidant compounds as they pertain to human health are considered in order to suggest optimal strategies for biofortified foods.Abstract:
Selenium supplementation in humans has been suggested for the prevention of chronic diseases including cardiovascular disease, cancer, and neurodegenerative diseases. Selenium biofortification of plants has been explored as a method for increasing selenium content of food and dietary selenium intake in humans. However, the effects of selenium biofortification on other dietary nutrients is often a secondary discussion. These effects are especially important to explore considering selenium-biofortified foods contain many other nutrients important to human health, such as other minerals and antioxidant compounds, which can make these foods superior to selenium supplementation alone. Investigation of selenium biofortification’s effect on these nutrients is necessary for a comprehensive human nutrition perspective on biofortification strategies. This review considers the effects of selenium biofortification on selenium content, other minerals, and antioxidant compounds as they pertain to human health in order to suggest optimal strategies for biofortification. Pre-clinical and clinical studies assessing the effects of consumption of selenium biofortified foods are also discussed.read more
Citations
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Effects of nationwide addition of selenium to fertilizers on foods, and animal and human health in Finland: From deficiency to optimal selenium status of the population
Georg Alfthan,Merja Eurola,Päivi Ekholm,Eija-Riitta Venäläinen,Tarja Root,Katja Korkalainen,Helinä Hartikainen,Pirjo Salminen,Veli Hietaniemi,Pentti Aspila,Antti Aro +10 more
TL;DR: The nationwide supplementation of fertilizers with sodium selenate is shown to be effective and safe in increasing the Se intake of the whole population and the health of animals has improved.
Journal ArticleDOI
Selenium biofortification in the 21 st century: status and challenges for healthy human nutrition.
TL;DR: The goal of this review is to report the present knowledge of the distribution and processes of Se in soil and at the plant-soil interface, and of Se behaviour inside the plant in terms of biofortification, to unravel the Se metabolic pathways that affect the nutritional value of edible plant products, various Se bioFortification strategies in challenging environments, as well as the impact of Se-enriched food on human health.
Journal ArticleDOI
Selenium Biofortification and Interaction With Other Elements in Plants: A Review.
TL;DR: This review focuses on summarizing the nutritional functions of Se and the current understanding of Se uptake by plant roots, translocation of Se from roots to shoots, and accumulation of Se in grains, and discussing the influence of nitrogen, phosphorus, and sulfur on the biofortification of Se.
Journal ArticleDOI
Selenium and Nano-Selenium Biofortification for Human Health: Opportunities and Challenges
Hassan El-Ramady,Salah E.-D. A. Faizy,Neama Abdalla,Hussein Taha,Éva Domokos-Szabolcsy,Miklós Fári,Tamer Elsakhawy,Alaa El-Dein Omara,Tarek A. Shalaby,Yousry Bayoumi,Said A. Shehata,Christoph-Martin Geilfus,Eric C. Brevik +12 more
TL;DR: Selenium and nano-selenium may be able to support and enhance the productivity of cultivated plants and animals under stressful conditions because they are antimicrobial and anti-carcinogenic agents, with antioxidant capacity and immune-modulatory efficacy.
Journal ArticleDOI
Potential Inhibitors for SARS-CoV-2 and Functional Food Components as Nutritional Supplement for COVID-19: A Review
Pushpendra Singh,Manish Kumar Tripathi,Mohammad Yasir,Ruchi Khare,Manoj Kumar Tripathi,Rahul Shrivastava +5 more
TL;DR: The functional food components as a nutritional supplement could be useful in preventing the COVID-19 and/or to improve the outcome during therapy and quick identification of potential inhibitors and immune-boosting functional food ingredients are crucial to combat this pandemic disease.
References
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Journal ArticleDOI
Free radicals, antioxidants and functional foods: Impact on human health
TL;DR: The present review provides a brief overview on oxidative stress mediated cellular damages and role of dietary antioxidants as functional foods in the management of human diseases.
Journal ArticleDOI
Oxidative Stress and Antioxidant Defense
TL;DR: In this review, the cellular oxidant and antioxidant systems are summarized and the cellular effects and mechanisms of the oxidative stress are discussed.
Journal ArticleDOI
Plant Polyphenols as Dietary Antioxidants in Human Health and Disease
TL;DR: It is suggested that long term consumption of diets rich in plant polyphenols offer protection against development of cancers, cardiovascular diseases, diabetes, osteoporosis and neurodegenerative diseases.
Journal ArticleDOI
Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin: A Randomized Controlled Trial
Larry C. Clark,Gerald F. Combs,Bruce W. Turnbull,Elizabeth H. Slate,Dan K. Chalker,James Chow,Loretta S. Davis,Renee A. Glover,Gloria F. Graham,Earl G. Gross,Arnon Krongrad,Jack L. Lesher,H. Kim Park,Beverly B. Sanders,Cameron L. Smith,J. Richard Taylor +15 more
TL;DR: Results from secondary end-point analyses support the hypothesis that supplemental selenium may reduce the incidence of, and mortality from, carcinomas of several sites and require confirmation in an independent trial of appropriate design before new public health recommendations regarding seenium supplementation can be made.
Journal ArticleDOI
Selenium and human health
TL;DR: The crucial factor that needs to be emphasised with regard to the health effects of selenium is the inextricable U-shaped link with status; whereas additional seenium intake may benefit people with low status, those with adequate-to-high status might be affected adversely and should not take selenum supplements.