Self‐assembly of peptide amphiphiles: From molecules to nanostructures to biomaterials
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TLDR
The strategies for using molecular self‐assembly as a toolbox to produce peptide amphiphile nanostructures and materials are highlighted and efforts to translate this technology into applications as therapeutics are reviewed.Abstract:
Peptide amphiphiles are a class of molecules that combine the structural features of amphiphilic surfactants with the functions of bioactive peptides and are known to assemble into a variety of nanostructures. A specific type of peptide amphiphiles are known to self-assemble into one-dimensional nanostructures under physiological conditions, predominantly nanofibers with a cylindrical geometry. The resultant nanostructures could be highly bioactive and are of great interest in many biomedical applications, including tissue engineering, regenerative medicine, and drug delivery. In this context, we highlight our strategies for using molecular self-assembly as a toolbox to produce peptide amphiphile nanostructures and materials and efforts to translate this technology into applications as therapeutics. We also review our recent progress in using these materials for treating spinal cord injury, inducing angiogenesis, and for hard tissue regeneration and replacement.read more
Citations
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Journal ArticleDOI
Electrostatically Tuned Self-Assembly of Branched Amphiphilic Peptides
TL;DR: It is found that the presence and distribution of charged groups on the hydrophilic branches of the peptide can modify the molecular configuration from extended to collapsed and the effects of charge distribution have important implications for the design and utility of functional materials based on peptides.
Journal ArticleDOI
Modeling Interactions within and between Peptide Amphiphile Supramolecular Filaments.
TL;DR: The simulations suggest that peptide amphiphiles with hydrophobic termini bend to reduce their interfacial energy with water, which may explain why these systems do not collapse into superstructures of bundled filaments.
Journal ArticleDOI
Potential sealing and repair of human FM defects after trauma with peptide amphiphiles and Cx43 antisense.
David W. Barrett,Babatunde O. Okesola,Eleni Costa,Christopher Thrasivoulou,David L. Becker,Alvaro Mata,Alvaro Mata,Jan Deprest,Jan Deprest,Anna L. David,Anna L. David,Tina T. Chowdhury +11 more
TL;DR: This work examined whether peptide amphiphiles functionalised with adhesive, migratory or regenerative sequences could be combined with amniotic fluid to form plugs that repair fetal membrane defects after trauma and co‐culture with connexin 43 (Cx43) antisense.
Book ChapterDOI
Low Molecular Weight Micelles
TL;DR: Micelles formed from low molecular weight amphiphiles are dynamic structures and there is continuous exchange of material between the mousellar aggregate and the bulk medium; this dynamic exchange has a negative effect on the stability and biocompatibility of micellar formulations.
References
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Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers
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Journal ArticleDOI
Peptide-amphiphile nanofibers: A versatile scaffold for the preparation of self-assembling materials
TL;DR: The scope of amino acid selection and alkyl tail modification in the peptide-amphiphile molecules are investigated, yielding nanofibers varying in morphology, surface chemistry, and potential bioactivity, demonstrating the chemically versatile nature of this supramolecular system.