Self‐assembly of peptide amphiphiles: From molecules to nanostructures to biomaterials
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TLDR
The strategies for using molecular self‐assembly as a toolbox to produce peptide amphiphile nanostructures and materials are highlighted and efforts to translate this technology into applications as therapeutics are reviewed.Abstract:
Peptide amphiphiles are a class of molecules that combine the structural features of amphiphilic surfactants with the functions of bioactive peptides and are known to assemble into a variety of nanostructures. A specific type of peptide amphiphiles are known to self-assemble into one-dimensional nanostructures under physiological conditions, predominantly nanofibers with a cylindrical geometry. The resultant nanostructures could be highly bioactive and are of great interest in many biomedical applications, including tissue engineering, regenerative medicine, and drug delivery. In this context, we highlight our strategies for using molecular self-assembly as a toolbox to produce peptide amphiphile nanostructures and materials and efforts to translate this technology into applications as therapeutics. We also review our recent progress in using these materials for treating spinal cord injury, inducing angiogenesis, and for hard tissue regeneration and replacement.read more
Citations
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Self-assembly of palmitoyl lipopeptides used in skin care products
Valeria Castelletto,Ian W. Hamley,Conor David Whitehouse,Paul J. Matts,Rosemarie Osborne,Ellen Schmidt Baker +5 more
TL;DR: The self-assembly of three cosmetically active peptide amphiphiles used in commercial skin care products is examined to probe the secondary structure, aggregate morphology, and the nanostructure to provide important insights relevant to the role of self-assembled aggregates on the reported collagen-stimulating properties of these PAs.
Journal ArticleDOI
One-Dimensional Supramolecular Nanoplatforms for Theranostics Based on Co-Assembly of Peptide Amphiphiles.
TL;DR: The coassembly of PAs with desirable functions may be a useful strategy for the generation of tailor-made biocompatible nanomaterials.
Journal ArticleDOI
Mechanochemical Encapsulation of Fullerenes in Peptidic Containers Prepared by Dynamic Chiral Self-Sorting and Self-Assembly.
Marek P. Szymański,Michał Wierzbicki,Miroslaw Gilski,Hanna Jędrzejewska,Marcin Sztylko,Piotr Cmoch,Aleksander Shkurenko,Mariusz Jaskolski,Agnieszka Szumna +8 more
TL;DR: The NMR spectra show the influence of the chiral environment on the symmetry of the fullerene molecules, which results in the differentiation of diastereotopic carbon atoms for C70 , and the X-ray structures provide unique information on the modes of peptide-fullerene interactions.
Journal ArticleDOI
Control of the Handedness of Self-assemblies of Dipeptides by the Chirality of Phenylalanine and Steric Hindrance of Phenylglycine.
TL;DR: Eight dipeptides, composed of phenylalanine and phenylglycine, that are able to self-assemble into twisted nanoribbons in deionized water are synthesized.
Journal ArticleDOI
Peptide Amphiphile Nanostructures for Targeting of Atherosclerotic Plaque and Drug Delivery
Miranda So,Neel A. Mansukhani,Erica B. Peters,Mazen Albaghdadi,Zheng Wang,Charles M. Rubert Pérez,Melina R. Kibbe,Melina R. Kibbe,Samuel I. Stupp +8 more
TL;DR: Results show that nanofibers functionalized with apolipoprotein‐mimetic peptides may be effective vehicles for intravascular targeted drug delivery to treat atherosclerosis.
References
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