Self‐assembly of peptide amphiphiles: From molecules to nanostructures to biomaterials
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TLDR
The strategies for using molecular self‐assembly as a toolbox to produce peptide amphiphile nanostructures and materials are highlighted and efforts to translate this technology into applications as therapeutics are reviewed.Abstract:
Peptide amphiphiles are a class of molecules that combine the structural features of amphiphilic surfactants with the functions of bioactive peptides and are known to assemble into a variety of nanostructures. A specific type of peptide amphiphiles are known to self-assemble into one-dimensional nanostructures under physiological conditions, predominantly nanofibers with a cylindrical geometry. The resultant nanostructures could be highly bioactive and are of great interest in many biomedical applications, including tissue engineering, regenerative medicine, and drug delivery. In this context, we highlight our strategies for using molecular self-assembly as a toolbox to produce peptide amphiphile nanostructures and materials and efforts to translate this technology into applications as therapeutics. We also review our recent progress in using these materials for treating spinal cord injury, inducing angiogenesis, and for hard tissue regeneration and replacement.read more
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Microfibers fabricated by non-covalent assembly of peptide and DNA for viral vector encapsulation and cancer therapy.
Jingye Yang,Ghayathri Balasundaram,Seong-Loong Lo,Eugene Choo Shi Guang,Junmin Xue,Jianxing Song,Andrew C.A. Wan,Jackie Y. Ying,Shu Wang +8 more
TL;DR: Self-assembled amphiphilic peptide units and supercoiled, circular double-stranded plasmid DNA are used as building blocks to form peptide/DNA fibers for virus encapsulation, and the bioactivity of viruses is well preserved.
Journal ArticleDOI
Robust supramolecular nanocylinders of naphthalene diimide in water.
Thomas Choisnet,David Canevet,Marc Sallé,Erwan Nicol,Frédérick Niepceron,Jacques Jestin,Olivier Colombani +6 more
TL;DR: Naphthalene-diimide-containing nanocylinders were formed by supramolecular self-assembly in water through cooperative hydrogen bonds between bis(urea) units, reinforced by hydrophobic and aromatic-stacking interactions.
Journal ArticleDOI
Structure-Dependent Antimicrobial Theranostic Functions of Self-Assembled Short Peptide Nanoagents
Inhye Kim,Seon-Mi Jin,Eun Hee Han,Eunhee Ko,Mija Ahn,Woo-Young Bang,Jeong Kyu Bang,Eunji Lee +7 more
TL;DR: A strategy to tune the MR relaxivity of tumor cell-targeted nanoagents and enhance the antimicrobial and anticancer activities of nanoagents based on rationally designed antimicrobial peptide (AMP) assembly is reported here.
Journal ArticleDOI
Improved MIN6 β-cell function on self-assembled peptide amphiphile nanomatrix inscribed with extracellular matrix-derived cell adhesive ligands.
Dong-Jin Lim,Sergey V. Antipenko,Jeremy B. Vines,Adinarayana Andukuri,Patrick T. J. Hwang,Nathan T. Hadley,Shibli M. Rahman,John A. Corbett,Ho-Wook Jun +8 more
TL;DR: These findings suggest that the self-assembled PA nanomatrix may be utilized to improve pancreatic islet transplantation for treating type 1 diabetes.
Journal ArticleDOI
The Synthesis of Dendritic EDOT-Peptide Conjugates and their Multistimuli-Responsive Self-Assembly into Supramolecular Nanorods and Fibers in Water
TL;DR: It is shown that changes in the pH and ionic strength are both able to independently trigger the self-assembly of the dendritic monomers into supramolecular nanorods and nanofibers.
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