Self‐assembly of peptide amphiphiles: From molecules to nanostructures to biomaterials
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TLDR
The strategies for using molecular self‐assembly as a toolbox to produce peptide amphiphile nanostructures and materials are highlighted and efforts to translate this technology into applications as therapeutics are reviewed.Abstract:
Peptide amphiphiles are a class of molecules that combine the structural features of amphiphilic surfactants with the functions of bioactive peptides and are known to assemble into a variety of nanostructures. A specific type of peptide amphiphiles are known to self-assemble into one-dimensional nanostructures under physiological conditions, predominantly nanofibers with a cylindrical geometry. The resultant nanostructures could be highly bioactive and are of great interest in many biomedical applications, including tissue engineering, regenerative medicine, and drug delivery. In this context, we highlight our strategies for using molecular self-assembly as a toolbox to produce peptide amphiphile nanostructures and materials and efforts to translate this technology into applications as therapeutics. We also review our recent progress in using these materials for treating spinal cord injury, inducing angiogenesis, and for hard tissue regeneration and replacement.read more
Citations
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Evolution of mechanics in α-helical peptide conjugated linear- and star-block PEG
TL;DR: This study shows that the dynamics of peptide folding and assembly for linear-P EG conjugated systems yield a percolated network, but the star-PEG conjugation systems yield discrete assemblies and remain viscous.
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Rational Coarse-Grained Molecular Dynamics Simulations of Supramolecular Anticancer Nanotubes
Anjela Manandhar,Kaushik Chakraborty,Phu K Tang,Myungshim Kang,Pengcheng Zhang,Honggang Cui,Honggang Cui,Sharon M. Loverde +7 more
TL;DR: Rational coarse grained molecular dynamics simulations of the self-assembly process and the structure and stability of pre-assembled nanotubes at longer time scales find aggregation between these DAs is at the sub-microsecond time scale is driven by directional aromatic interactions between the drugs.
Journal ArticleDOI
Peptide-Based Nanostructures for Cancer Diagnosis and Therapy
TL;DR: The basic peptide structures are summarized to provide a whole image of pep-NPs and the diagnostic strategies based on different imaging modalities and recent therapeutic applications of pembrokeshire nanoparticles for cancer are reviewed.
Journal ArticleDOI
Probing micro-solvation in “numbers”: the case of neutral dipeptides in water
Panteleimon G. Takis,Konstantinos D. Papavasileiou,Loukas D. Peristeras,Vasilios S. Melissas,Anastassios N. Troganis +4 more
TL;DR: A novel NMR spectroscopic study achieves for the first time the quantification of the directly interacting water molecules with several neutral dipeptides, shedding light on the biomolecular micro-solvation processes and behaviour in various solvents.
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Length-dependent proteolytic cleavage of short oligopeptides catalyzed by matrix metalloprotease-9.
TL;DR: The results suggest that the substitute group at the N-terminal and the length of peptides significantly affect the position of the cleavage site on the oligopeptides, which provides a useful insight for the design of small peptide derivatives as the substrates of MMP-9.
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Peptide-amphiphile nanofibers: A versatile scaffold for the preparation of self-assembling materials
TL;DR: The scope of amino acid selection and alkyl tail modification in the peptide-amphiphile molecules are investigated, yielding nanofibers varying in morphology, surface chemistry, and potential bioactivity, demonstrating the chemically versatile nature of this supramolecular system.