Journal ArticleDOI
Self-reporter shikonin-Act-loaded solid lipid nanoparticle: formulation, physicochemical characterization and geno/cytotoxicity evaluation.
TLDR
To enhance shikonin-Act anti-proliferation properties, it was successfully incorporated in Solid Lipid Nanoparticles (SLNs) by the hot homogenization and entrapment efficiency of drug in SLNs was determined by ultrafiltration method.About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2014-08-01. It has received 48 citations till now. The article focuses on the topics: Drug carrier & Solid lipid nanoparticle.read more
Citations
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Journal ArticleDOI
Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems
Vijay Mishra,Kuldeep K. Bansal,Asit Verma,Nishika Yadav,Sourav Thakur,Kalvatala Sudhakar,Jessica M. Rosenholm +6 more
TL;DR: Light is shed on different aspects of SLNs including fabrication and characterization techniques, formulation variables, routes of administration, surface modifications, toxicity, and biomedical applications.
Journal ArticleDOI
Preclinical safety of solid lipid nanoparticles and nanostructured lipid carriers: Current evidence from in vitro and in vivo evaluation.
TL;DR: In the present work, published data on in vitro and in vivo compatibility of SLN/NLC have been surveyed to provide evidence of high biocompatibility distinguished by intended administration route and critical factors and possible weak points in SLN-NLC formulations are identified.
Journal ArticleDOI
Shikonin derivatives for cancer prevention and therapy
TL;DR: Shikonin exerts additive and synergistic interactions in combination with established chemotherapeutics, immunotherapeutic approaches, radiotherapy and other treatment modalities, which further underscores the potential of this phytochemical to be integrated into standard treatment regimens.
Journal ArticleDOI
AS1411 aptamer-decorated cisplatin-loaded poly(lactic-co-glycolic acid) nanoparticles for targeted therapy of miR-21-inhibited ovarian cancer cells.
TL;DR: The targeted delivery of chemotherapeutics to the oncomiR-inhibited cells may find a robust application in cancer chemo/gene therapy.
Journal ArticleDOI
Lipid nanoparticles as carriers for bioactive delivery
TL;DR: In this article, the authors present a bird's eye view on various aspects of lipid nanoparticles as carriers of bioactive molecules that is, synthesis, characterization, advantage, disadvantage, toxicity, and application in the medical field.
References
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Journal ArticleDOI
A simple technique for quantitation of low levels of DNA damage in individual cells
TL;DR: Human lymphocytes were exposed to X-irradiation or treated with H2O2 and the extent of DNA migration was measured using a single-cell microgel electrophoresis technique under alkaline conditions and this technique appears to be sensitive and useful for detecting damage and repair in single cells.
Journal ArticleDOI
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
TL;DR: Relevant issues for the introduction of SLN to the pharmaceutical market, such as status of excipients, toxicity/tolerability aspects and sterilization and long-term stability including industrial large scale production are discussed.
Journal ArticleDOI
Solid lipid nanoparticles: Production, characterization and applications
W. Mehnert,Karsten Mäder +1 more
TL;DR: An overview about the selection of the ingredients, different ways of SLN production and SLN applications, and the in vivo fate of the carrier are presented.
Journal ArticleDOI
Nanoparticle Surface Charges Alter Blood–Brain Barrier Integrity and Permeability
TL;DR: In this article, the effect of neutral, anionic and cationic charged nanoparticles on the blood-brain barrier (BBB) and brain permeability was evaluated by in situ rat brain perfusion.