Serum thyroglobulin autoantibodies: prevalence, influence on serum thyroglobulin measurement, and prognostic significance in patients with differentiated thyroid carcinoma.
Carole A. Spencer,M Takeuchi,M. Kazarosyan,C. C. Wang,Richard B. Guttler,Peter Singer,Shireen Fatemi,Jonathan S. LoPresti,John T. Nicoloff +8 more
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TLDR
The RIA method used in this study provided more clinically appropriate serum Tg values in the group of TgAb-positive patients with metastatic DTC and may be an additional clinically useful tumor marker parameter for following T gAb- positive patients.Abstract:
The prevalence of circulating thyroid autoantibodies (TgAb or antithyroid peroxidase) was increased nearly 3-fold in patients with differentiated thyroid cancers (DTC) compared with the general population (40% vs. 14%, respectively). Serum TgAb (with or without antithyroid peroxidase) was present in 25% of DTC patients and 10% of the general population. Serial postsurgical serum TgAb and serum Tg patterns correlated with the presence or absence of disease. Measurements of serum Tg were made in 87 TgAb-positive sera by a RIA and two immunometric assay (IMA) methods to study TgAb interference. TgAb interference, defined as a significant intermethod discordance (>41.7% coefficient of variation) between the Tg RIA and Tg IMA values relative to TgAb-negative sera, was found in 69% of the TgAb-positive sera. TgAb interference was characterized by higher Tg RIA vs. IMA values and was, in general, more frequent and severe in sera containing high TgAb concentrations. However, some sera displayed marked interference when serum TgAb was low (1-2 IU/mL), whereas other sera with very high TgAb values (>1000 IU/mL) displayed no interference. An agglutination method was found to be too insensitive to detect low TgAb concentrations (1-10 IU/mL) causing interference. Exogenous Tg recovery tests were an unreliable means for detecting TgAb interference. Specifically, the exogenous Tg recovered varied with the type and amount of Tg added and the duration of incubation employed. Further, recoveries of more than 80% were found for some sera displaying gross serum RIA/IMA discordances. The measurement of serum Tg in DTC patients with circulating TgAb is currently problematic. It is important to use a Tg method that provides measurements that are concordant with tumor status. IMA methods are prone to underestimate serum when TgAb is present, increasing the risk that persistent or metastatic DTC will be missed. The RIA method used in this study provided more clinically appropriate serum Tg values in the group of TgAb-positive patients with metastatic DTC. Furthermore, as serial serum TgAb measurements paralleled serial serum Tg RIA measurements, TgAb concentrations may be an additional clinically useful tumor marker parameter for following TgAb-positive patients. Disparities between serial serum Tg and TgAb measurements might alert the physician to the possibility of TgAb interference with the serum Tg measurement and prompt a more cautious use of such data for clinical decision-making.read more
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Patent
Methods for analysis of free and autoantibody-bound biomarkers and associated compositions, devices, and systems
TL;DR: In this article, the authors present methods, compositions, and kits associated with analyzing, enriching, and/or isolating a biomarker or analyte in a biological sample.
Journal ArticleDOI
Salivary gland function in women with Hashimoto's thyroiditis without xerostomia and the correlation with auto-thyroid antibodies
TL;DR: Women with HT without xerostomia may not have salivary functional impairment during hypothyroidism, and gland semi-quantitative parameters were correlated with levels of thyroid-stimulating hormone, TGAb, and TPOAb in the HT and DTC groups.
Journal ArticleDOI
Clinical outcome of patients with differentiated thyroid cancer and raised antithyroglobulin antibody levels: a retrospective study.
Manish Ora,Aftab Hasan Nazar,Prabhakar Mishra,Sukanta Barai,Amitabh Arya,Prasanta Pradhan,Sanjay Gambhir +6 more
TL;DR: High post-operative TgAb levels and central compartment lymph nodal metastases are risk factors for IR and RIT leads to a significant fall in the TGAb in these patients.
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Interpretation of Sensitive Thyroid Autoantibody Assay
Bo Hyun Kim,In Ju Kim +1 more
TL;DR: A recently developed second-generation assay for TBII uses recombinant human TSHR, expressed in eukaryotic cells, this assay showed better diagnostic sensitivity and specificity than the conventional TBIi assay.
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Carcinoma de tireóide em crianças e adolescentes - revisão de seis casos
Daniela V. M. Szeliga,Nuvarte Setian,Leonardo D. Passos,Thais M. R. Lima,Thais Della Manna,Hilton Kuperman,Durval Damiani,Vaê Dichtchekenian +7 more
TL;DR: The findings support the clinical impression that children and adolescents with thyroid carcinoma have a good prognosis: there were no deaths in this follow-up of 17 years, and data are similar to those in the literature, that reveals low mortality in these cases.
References
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Long-Term Results of Treatment of 283 Patients with Lung and Bone Metastases from Differentiated Thyroid Carcinoma
M. Schlumberger,M. Tubiana,F. de Vathaire,Catherine Hill,P. Gardet,Jean-Paul Travagli,Philippe Fragu,Jean Lumbroso,Bernard Caillou,Claude Parmentier +9 more
TL;DR: The results suggest that the aim of management should be to detect and treat metastases in patients with thyroid cancer as early as possible.
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Elevated serum thyroglobulin. A marker of metastases in differentiated thyroid carcinomas.
A J Herle,R P Uller +1 more
TL;DR: The data support the thesis that in differentiated thyroid carcinoma serum thyroglobulin levels are elevated when metastases develop after initial treatment and represent a simple and valuable adjunct in the posttreatment follow up of patients with differentiated thyroid cancer.
Journal ArticleDOI
Thyroglobulin measurement. Techniques, clinical benefits, and pitfalls.
TL;DR: Physicians need to consider a number of factors before selecting a laboratory to perform Tg measurements in patients with differentiated thyroid carcinoma, including assay sensitivity, as judged by the discrimination between lower limit of the euthyroid range and the functional sensitivity limit, as well as assay specificity, especially with respect to serum TgAb interference.
Journal ArticleDOI
The correlation between papillary thyroid carcinoma and lymphocytic infiltration in the thyroid gland
Sunao Matsubayashi,Keisuke Kawai,Y. Matsumoto,T. Mukuta,Tetsuya Morita,K Hirai,Fumio Matsuzuka,K.-I. Kakudoh,Kanji Kuma,Hajime Tamai +9 more
TL;DR: Lymphocytic infiltration surrounding the tumor or inside the tumor in PTC might be of use as a means for predicting a favorable prognosis and class II or class III patients with no lymphocytic infiltrate had a high rate of recurrence.
Journal ArticleDOI
Current status and performance goals for serum thyroglobulin assays.
TL;DR: Optimal performance goals are recommended for manufacturers developing and laboratories and physicians selecting a serum Tg method to use for serial long-term monitoring of thyroid cancer patients.
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