Journal ArticleDOI
Severe cachexia in mice inoculated with interferon‐γ‐producing tumor cells
Patrick Matthys,Roger Dukmans,Paul Proost,Jo Van Damme,Hubertine Heremans,H Sobis,Alfons Billiau +6 more
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TLDR
The data suggest that, among the humoral factors responsible for cancer‐associated cachexia, IFN‐γ plays a prominent role, and that the presence of the tumor cells was also required for cachexia to develop.Abstract:
Nude mice were inoculated with CHO/IFN-gamma cells, a line of Chinese hamster ovary tumor cells, that had been genetically engineered to produce murine IFN-gamma. Severe cachexia, as evident from body weight loss and reduced food intake, occurred in these mice, but not in those injected with CHO/control cells, i.e. the original, non-IFN-gamma-producing line. The essential role of IFN-gamma in the pathogenesis of cachexia was confirmed by the demonstration that monoclonal antibodies (MAbs) against IFN-gamma, given prior to injection of the tumor cells, prevented cachexia. In addition to IFN-gamma, the presence of the tumor cells was also required for cachexia to develop. As evident from pair-feeding experiments, reduced food intake could only partially account for the rapid and extensive body-weight loss. Cachexia was characterized by a marked reduction in the amount of interscapular fat tissue. Injected tumor cells exclusively invaded intraperitoneal adipose tissue and elicited an inflammatory cell infiltrate, indicating that interscapular fat loss was due to humoral factors. Our data suggest that, among the humoral factors responsible for cancer-associated cachexia, IFN-gamma plays a prominent role.read more
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Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
Marcia M. Shull,Ilona Ormsby,Ann B. Kier,Sharon A. Pawlowski,Ronald J. Diebold,Moying Yin,Ruth D. Allen,Charles L. Sidman,Gabriele Proetzel,Dawn Calvin,Nikki Annunziata,Thomas Doetschman +11 more
TL;DR: TGF-β1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions.
Journal ArticleDOI
Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene.
TL;DR: The TSP homologous domain containing the TSP type I motif of ADAMTS-1 is functional for binding to heparin, suggesting that ADAM-TS- 1 may be a gene whose expression is associated with various inflammatory processes as well as development of cancer cachexia.
Journal ArticleDOI
Biology of Cachexia
TL;DR: A polyunsaturated fatty acid, eicosapentaenoic acid, attenuates the action of such catabolic factors and has been shown to stabilize the process of wasting and resting energy expenditure in patients with pancreatic cancer.
Journal ArticleDOI
Cancer cachexia is regulated by selective targeting of skeletal muscle gene products
Swarnali Acharyya,Katherine J. Ladner,Lori L. Nelsen,Jeffrey S. Damrauer,Peter J. Reiser,Steven J. Swoap,Denis C. Guttridge +6 more
TL;DR: It is demonstrated, using in vitro and in vivo models of muscle wasting, that cachectic factors are remarkably selective in targeting myosin heavy chain, and this sheds new light on cancer cachexia by revealing that wasting does not result from a general downregulation of muscle proteins but rather is highly selective as to which proteins are targeted during the wasting state.
Journal ArticleDOI
Characterization of a cancer cachectic factor
TL;DR: The isolation of an antibody cloned from splenocytes of mice transplanted with the MAC16 tumour suggests that cachexia in mice and humans may be produced by the same material, a proteoglycan of relative molecular mass 24K which produces Cachexia in vivo by inducing catabolism of skeletal muscle.
References
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Journal ArticleDOI
Prognostic effect of weight loss prior tochemotherapy in cancer patients
William D. Dewys,Colin B. Begg,Philip T. Lavin,Pierre R. Band,John M. Bennett,Joseph R. Bertino,Martin H. Cohen,Harold O. Douglass,Paul F. Engstrom,Ediz Z. Ezdinli,John Horton,Gerhard J. Johnson,Charles G. Moertel,Martin M. Oken,Charles P. Perlia,Charles Rosenbaum,Murray N. Silverstein,Roland T. Skeel,Robert W. Sponzo,Douglass C. Tormey +19 more
TL;DR: The prognostic effect of weight loss prior to chemotherapy was analyzed using data from 3,047 patients enrolled in 12 chemotherapy protocols of the Eastern Cooperative Oncology Group and increased with increasing number of anatomic sites involved with metastases, but within categories of Anatomic involvement, weight loss was associated with decreased median survival.
Journal ArticleDOI
Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation.
Kevin J. Tracey,H Wei,K R Manogue,Yuman Fong,David G. Hesse,H T Nguyen,G C Kuo,Bruce Beutler,R S Cotran,Anthony Cerami +9 more
TL;DR: Data suggests that the exposure of the normal host to cachectin is capable of inducing a pathophysiological syndrome of cachexia, anemia, and inflammation similar to that observed during inflammatory states or malignancy.
Journal ArticleDOI
Tumors secreting human TNF/cachectin induce cachexia in mice
Oliff Allen I,Deborah Defeo-Jones,Mark E. Boyer,Douglas Martinez,David M. Kiefer,G A Vuocolo,Abigail Wolfe,Susan H. Socher +7 more
TL;DR: It is concluded that mice bearing tumors that secrete TNF/cachectin develop progressive wasting and die more quickly than mice bearing control tumors.
Journal ArticleDOI
Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.
J Van Snick,S Cayphas,Anne Vink,Catherine Uyttenhove,Pierre Coulie,Michael R. Rubira,Richard J. Simpson +6 more
TL;DR: A T-cell derived lymphokine was identified by its ability to support the growth of a subset of B-cell hybridomas as mentioned in this paper, which represented a major proportion of rat-mouse hybridomas.
Journal Article
Purification and NH2-terminal Amino-acid-sequence of a New T-cell Derived Lymphokine With Growth-factor Activity for B-cell Hybridomas
TL;DR: A T-cell-derived lymphokine was identified by its ability to support the growth of a subset of B-cell hybridomas and was provisionally designated interleukin-HP1 (where H stands for hybridoma and P stands for plasmacytoma).
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Prognostic effect of weight loss prior tochemotherapy in cancer patients
William D. Dewys,Colin B. Begg,Philip T. Lavin,Pierre R. Band,John M. Bennett,Joseph R. Bertino,Martin H. Cohen,Harold O. Douglass,Paul F. Engstrom,Ediz Z. Ezdinli,John Horton,Gerhard J. Johnson,Charles G. Moertel,Martin M. Oken,Charles P. Perlia,Charles Rosenbaum,Murray N. Silverstein,Roland T. Skeel,Robert W. Sponzo,Douglass C. Tormey +19 more