Journal ArticleDOI
Shapes, domain organizations and flexibility of laminin and fibronectin, two multifunctional proteins of the extracellular matrix.
Jürgen Engel,Erich Odermatt,Andreas Engel,Joseph A. Madri,Heinz Furthmayr,Heilwig Rohde,Rupert Timpl +6 more
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TLDR
Electron microscopic images of the shapes and dimensions of laminin, of fragments of laminationin, and of fibronectin are consistent with the specific molecular weights and with the hydrodynamic properties determined in solution.About:
This article is published in Journal of Molecular Biology.The article was published on 1981-07-25. It has received 641 citations till now. The article focuses on the topics: Laminin.read more
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Fibronectins: multifunctional modular glycoproteins.
TL;DR: The current understanding of the structure and properties of fibronectins is reviewed to focus on overall concepts, recent developments and promising future research directions in this rapidly expanding field.
Journal ArticleDOI
Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma.
Hynda K. Kleinman,Mary L. McGarvey,Lance A. Liotta,Pamela Gehron Robey,Karl Tryggvason,George R. Martin +5 more
TL;DR: It is indicated that lysine-derived cross-links and disulfide bonds stabilize the collagenous component in the matrix but not the laminin or the heparan sulfate proteoglycan.
Journal ArticleDOI
Form and function: the laminin family of heterotrimers.
TL;DR: The laminins are a family of glycoproteins that provide an integral part of the structural scaffolding of basement membranes in almost every animal tissue and have unique and shared cell interactions mediated by integrins, dystroglycan, and other receptors.
Journal ArticleDOI
Structure and biological activity of basement membrane proteins
TL;DR: Observations of major structural proteins of basement membranes have provided a more defined understanding of basement membrane function and the definition of new research goals in the future.
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Laminin and Other Basement Membrane Components
George R. Martin,Rupert Timpl +1 more
TL;DR: This paper presents a meta-modelling framework for designing modular models of BASEMENT MEMBRANE STRUCTURE and some of the models developed so far have shown high levels of similarity to conventional models.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
Laminin--a glycoprotein from basement membranes.
Rupert Timpl,H Rohde,Pamela Gehron Robey,Stephen I. Rennard,Jean-Michel Foidart,George R. Martin +5 more
TL;DR: Investigation of a large noncollagenous glycoprotein isolated from a mouse tumor that produces basement membrane shows that it is produced by a variety of cultured cells, suggesting that this protein or an immunologically related protein is a constituent of the basement membranes of these tissues.
Journal ArticleDOI
Röntgenuntersuchung gelöster Fadenmoleküle
O. Kratky,G. Porod +1 more
TL;DR: In this paper, it was shown that the abscissa of the intersecting point of the 1/v2 and 1 /v branches, when extrapolated to the transition region, is connected in a characteristic way with the statistical chain element or the length of persistance, which represent two different measures for the stiffness of the chain molecule.
Journal ArticleDOI
Substructure of the myosin molecule: I. Subfragments of myosin by enzymic degradation
TL;DR: Under suitable experimental conditions, low concentrations of papain can split the enzymic globular regions of myosin from the structural α-helical rod, leaving the latter intact along its length.