Journal ArticleDOI
Signaling pathways for the vascular effects of hydrogen sulfide.
TLDR
An array of signaling pathways in vascular tissues is enlisted by endogenous H2S, and an insightful understanding of these signaling mechanisms would help elucidate the pathogenesis of selective cardiovascular diseases and develop related therapeutic interventions by targeting H 2S metabolism.Abstract:
Purpose of reviewThe physiological and pathophysiological importance of endogenous hydrogen sulfide to cardiovascular health has been recognized in recent years. The signaling mechanisms underlying the multifaceted vascular effects of H2S, on the contrary, have been unclear. This article reviews recread more
Citations
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Journal ArticleDOI
Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed
TL;DR: The important life-supporting role of hydrogen sulfide (H(2)S) has evolved from bacteria to plants, invertebrates, vertebrate, vertebrates, and finally to mammals, but over the centuries it had only been known for its toxicity and environmental hazard.
Journal ArticleDOI
Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling.
Eva-Maria Hanschmann,José R. Godoy,Carsten Berndt,Christoph Hudemann,Christopher Horst Lillig +4 more
TL;DR: This review summarizes the almost 50 years of research on these proteins, focusing primarily on data from vertebrates and mammals, that is, their potential impact and functions in different cell types, tissues, and various pathological conditions.
Journal ArticleDOI
Molecular Biology of Atherosclerosis
TL;DR: Key signaling pathways are presented to provide a context for the gene manipulations summarized herein and will undoubtedly provide a rich resource for future innovation toward intervention and prevention of the number one cause of death in the modern world.
Journal ArticleDOI
Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools.
TL;DR: The suitability of proposed 'biomarkers' of H2S synthesis and metabolism are critically discussed, and the complexities of the currently used pharmacological H 2S 'donor' molecules and 'specific' H2 S synthesis inhibitors are highlighted in their application to studying the role of H1N1 in human disease.
Journal ArticleDOI
Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl
Miriam M. Cortese-Krott,Gunter G. C. Kuhnle,Alex Dyson,Bernadette O. Fernandez,Marian Grman,Jenna F. DuMond,Mark P. Barrow,George McLeod,Hidehiko Nakagawa,Karol Ondrias,Péter Nagy,S. Bruce King,Joseph E. Saavedra,Larry K. Keefer,Mervyn Singer,Malte Kelm,Anthony R. Butler,Martin Feelisch +17 more
TL;DR: The results unveil an unexpectedly rich network of coupled chemical reactions between NO and H2S/sulfide, suggesting that the bioactivity of either transmitter is governed by concomitant formation of polysulfides and anionic S/N-hybrid species.
References
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Journal ArticleDOI
H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase
Guangdong Yang,Guangdong Yang,Lingyun Wu,Bo Jiang,Wei Yang,Jiansong Qi,Kun Cao,Qinghe Meng,Asif K. Mustafa,Weitong Mu,Shengming Zhang,Solomon H. Snyder,Rui Wang,Rui Wang +13 more
TL;DR: It is shown that H2S is physiologically generated by cystathionine γ-lyase (CSE) and that genetic deletion of this enzyme in mice markedly reduces H 2S levels in the serum, heart, aorta, and other tissues.
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The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener
TL;DR: It is demonstrated that H2S is an important endogenous vasoactive factor and the first identified gaseous opener of KATP channels in vascular SMCs and production from vascular tissues was enhanced by nitric oxide.
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Two’s company, three’s a crowd: can H2S be the third endogenous gaseous transmitter?
TL;DR: It is hypothesized that H2S is the third endogenous signaling gasotransmitter, besides nitric oxide and carbon monoxide, and this positioning will open an exciting field‐H2S physiology‐encompassing realization of the interaction of H1N1 and other gasOTransmitters, sulfurating modification of proteins, and the functional role of H2Sin multiple systems.
Journal ArticleDOI
The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide.
TL;DR: In this paper, the authors showed that mRNA for another H2S producing enzyme, cystathionine gamma-lyase, is expressed in the ileum, portal vein, and thoracic aorta.
Journal ArticleDOI
H2S Signals Through Protein S-Sulfhydration
Asif K. Mustafa,Moataz M. Gadalla,Nilkantha Sen,Seyun Kim,Weitong Mu,Sadia K. Gazi,Roxanne K. Barrow,Guangdong Yang,Rui Wang,Solomon H. Snyder +9 more
TL;DR: Ex vivo endogenous H2S physiologically modifies cysteine residues in many proteins, including glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and actin, converting Cysteine -SH groups to -SSH groups in a process the authors call S-sulfhydration.