Journal ArticleDOI
Simple and efficient syntheses of novel benzo[4,5]imidazo[1,2-a]pyridine derivatives
Fereshteh Goli-Garmroodi,Marzieh Omidi,Mina Saeedi,Farhad Sarrafzadeh,Ali Rafinejad,Mohammad Mahdavi,Ghasem Rezanejade Bardajee,Tahmineh Akbarzadeh,Loghman Firoozpour,Abbas Shafiee,Alireza Foroumadi,Alireza Foroumadi +11 more
TLDR
In this article, a series of benzo[4,5]imidazo[1,2-a ]pyridine derivatives is synthesized through the reaction of 2-(1 H -benzo[d ]imidazol-2-yl)acetonitrile and different ethyl 2,4-dioxo-4-arylbutanoate derivatives in the presence of piperidine in refluxing EtOH.About:
This article is published in Tetrahedron Letters.The article was published on 2015-01-28. It has received 20 citations till now. The article focuses on the topics: Piperidine & Pyridine.read more
Citations
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Facile, novel and efficient synthesis of new pyrazolo[3,4-b]pyridine products from condensation of pyrazole-5-amine derivatives and activated carbonyl groups
Aseyeh Ghaedi,Ghasem Rezanejade Bardajee,Ahmad Mirshokrayi,Mohammad Mahdavi,A. Shafiee,Tahmineh Akbarzadeh +5 more
TL;DR: In this paper, an efficient synthesis of novel ethyl-1,3,4-triphenyl- 1H-pyrazolo[3, 4-b]pyridine-6-carboxylate products has been achieved via condensation of pyrazole-5-amine derivatives and activated carbonyl groups, in refluxing acetic acid.
Journal ArticleDOI
Synthesis of novel indolo[3,2-c]isoquinoline derivatives bearing pyrimidine, piperazine rings and their biological evaluation and docking studies against COVID-19 virus main protease.
TL;DR: Replacement of fluorine, methyl and methoxy of synthetic compounds for noteworthy antimicrobial, antioxidant, anticancer and anti-tuberculosis activities, as well as other biological activities and SAR are proposed.
Journal ArticleDOI
Copper-catalyzed four-component synthesis of imidazo[1,2-a]pyridines via sequential reductive amination, condensation, and cyclization
TL;DR: In this paper, a four-component approach for the synthesis of 2,3-disubstituted imidazo[1,2-a]pyridines is described.
Journal ArticleDOI
Solvatochromic benzo[h] coumarins: Synthesis, solvatochromism, NLO and DFT study
Umesh Warde,Nagaiyan Sekar +1 more
TL;DR: In this paper, three benzo[h] coumarins were synthesized and analyzed for their potential NLOphoric properties using Knoevenagel condensation method by reacting hydroxyl-naphthalene aldehyde with cyano-methylelene-benzazoles.
Journal ArticleDOI
Recent Developments in the Synthesis of Pyrido[1,2-a]benzimidazoles
Rajni Khajuria,Sk. Rasheed,Sk. Rasheed,Chhavi Khajuria,Kamal K. Kapoor,Parthasarathi Das,Parthasarathi Das,Parthasarathi Das +7 more
TL;DR: The main advances in the synthesis of pyrido[1,2-a]benzimidazoles via metal-mediated and metal-free reactions from 2000 to 2016 are discussed in this paper.
References
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Journal ArticleDOI
A Direct Intramolecular C−H Amination Reaction Cocatalyzed by Copper(II) and Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido[1,2-a]benzimidazoles from N-Aryl-2-aminopyridines
TL;DR: A novel and efficient synthesis of pyrido[1,2-a]benzimidazoles through direct intramolecular aromatic C-H amination of N-aryl-2-aminopyridines has been developed and mechanistic studies suggest that a Cu(III)-catalyzed electrophilic aromatic substitution (S(E)Ar) pathway is operating in this process.
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Novel Cyano- and Amidino-Substituted Derivatives of Styryl-2-Benzimidazoles and Benzimidazo[1,2-a]quinolines. Synthesis, Photochemical Synthesis, DNA Binding, and Antitumor Evaluation, Part 3
Marijana Hranjec,Marijeta Kralj,Ivo Piantanida,Mirela Sedić,Lidija Šuman,Krešimir Pavelić,Grace Karminski-Zamola +6 more
TL;DR: The most active imidazolyl-substituted compound 19 inhibits topoisomerase II and induces strong G2/M cell cycle arrest, pointing to the impairment in mitotic progression.
Journal ArticleDOI
Novel synthetic strategy of carbolines via palladium-catalyzed amination and arylation reaction
TL;DR: In this article, four parent carbolines and their corresponding 5- or 9-methylsulfonyl derivatives were synthesized by the palladium-catalyzed intramolecular arylation reaction of ortho-bromo-substituted anilinopyridines.
Journal ArticleDOI
On the Importance of an Acid Additive in the Synthesis of Pyrido[1,2‐a]benzimidazoles by Direct Copper‐Catalyzed Amination
Kye-Simeon Masters,Tom R. M. Rauws,Ashok K. Yadav,Wouter A. Herrebout,Benjamin J. van der Veken,Bert U. W. Maes +5 more
TL;DR: The synthesis of pyrido[1,2-a]benzimidazoles by a transition-metal-catalyzed intramolecular CH amination approach from N-arylpyridin-2-amines was explored and a synthetic procedure that eliminated the need for preactivation of the 1-position of the 2-chloroarylamino entity could be developed.
Journal ArticleDOI
Novel Amidino-Substituted Thienyl- and Furylvinylbenzimidazole: Derivatives and Their Photochemical Conversion into Corresponding Diazacyclopenta[c]fluorenes. Synthesis, Interactions with DNA and RNA, and Antitumor Evaluation. 4
Marijana Hranjec,Ivo Piantanida,Marijeta Kralj,Lidija Šuman,Krešimir Pavelić,Grace Karminski-Zamola +5 more
TL;DR: Both nonfused and fused thiophene-containing imidazolyl derivatives should be considered as promising lead compounds for further investigation.